grant
The role of N6-methyladenosine RNA modification in programmed and aberrant DNA mutagenesis in B cells
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 9 Sept 2020Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2026AICDAAICDA proteinAID geneAID proteinAberrant ChromosomeAblationAllelesAllelomorphsAntibodiesAntibody AffinityAntigensAssayAutomobile DrivingAuxinsB blood cellsB cellB cellsB-Cell DeficiencyB-Cell DevelopmentB-CellsB-LymphocytesB-cellBindingBinding ProteinsBioassayBiochemicalBiologicalBiological AssayBiologyCD19CD19 geneCDA2 proteinCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell Culture TechniquesCell FunctionCell Growth in NumberCell LineCell LineageCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationChromatinChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosomal InstabilityChromosomal dislocationChromosomal translocationChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome InstabilityChromosome abnormalityClass SwitchingClass SwitchingsClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCodeCoding SystemComplexCoupledCytogenetic AberrationsCytogenetic AbnormalitiesCytoplasmic GranulesDLBCLDNADNA AlterationDNA MaintenanceDNA RearrangementDNA RecombinationDNA Sequence AlterationDNA Single Strand BreakDNA StabilityDNA StructureDNA mutationDataDeoxyribonucleic AcidDiffuse Large B-Cell LymphomaDisadvantagedDiseaseDisorderDouble-Stranded DNAEnzyme GeneEnzymesEventFrequenciesFunctional RNAFundingGene ActivationGene ExpressionGene RearrangementGene TranscriptionGenerationsGenesGeneticGenetic AlterationGenetic ChangeGenetic RecombinationGenetic TranscriptionGenetic TranslocationGenetic defectGenetic mutationGenetics-MutagenesisGenomeGenome InstabilityGenomic InstabilityGenomicsGerm LinesGerminal CenterHeavy-Chain ImmunoglobulinsHeterodimerizationHumanHybridsIGHIGH@ gene clusterIg GenesIg Somatic HypermutationIgH locusImmune GlobulinsImmunizeImmunoglobulin Class SwitchingImmunoglobulin Class SwitchingsImmunoglobulin GenesImmunoglobulin Heavy Chain GenesImmunoglobulin Heavy GeneImmunoglobulin Heavy LocusImmunoglobulin Isotype-Switch RecombinationImmunoglobulin Somatic HypermutationImmunoglobulin Switch RecombinationImmunoglobulin V(D)J RearrangementImmunoglobulinsIsotype SwitchingIsotype SwitchingsLaboratoriesLeadLigand Binding ProteinLigand Binding Protein GeneLight-Chain ImmunoglobulinsLoxP-flanked alleleLymphomagenesisMalignant CellMeasurementMeasuresMediatingMethylationMiceMice MammalsMicroscopyModern ManModificationMolecular InteractionMultiple MyelomaMurineMusMutagenesisMutagenesis Molecular BiologyMutationNon-Polyadenylated RNANoncoding RNANontranslated RNAPathway interactionsPb elementPeyer's PatchesPlasma-Cell MyelomaPlayPost-Transcriptional ControlPost-Transcriptional RegulationPreventionProcessPropertyProtein BindingProteinsPublishingPutative RNA-Binding RegionRNARNA Binding DomainRNA DegradationRNA EditingRNA ExpressionRNA Gene ProductsRNA Recognition MotifRNA SeqRNA methylationRNA sequencingRNA, Messenger, EditingRNAseqRNP DomainRNP MotifRNP-1 SignatureReaderRecombinationResearch DesignResidualResidual stateResolutionRestRibonucleic AcidRoleSequence AlterationSiteSomatic MutationSterilityStrains Cell LinesStructureStructure of germinal center of lymph nodeStudy TypeSubcellular ProcessSwitch RecombinationSystemTamoxifenTranscriptTranscriptionUntranslated RNAV(D)J RearrangementV(D)J RecombinationVDJ rearrangementVDJ recombinationactivation-induced cytidine deaminaseactivation-induced deaminaseadaptive immune responseantigen antibody affinitybiologicbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquesbound proteincancer cellcell culturecell culturescellular developmentchromosomal defectchromosome defectchromosome dislocationchromosome translocationcultured cell linedemethylationdrivingds-DNAdsDNAepigenomicsexosomeexperimentexperimental researchexperimental studyexperimentsfloxedfloxed allelegenome editinggenome integritygenome mutationgenomic alterationgenomic editinggenomic integritygranuleheavy metal Pbheavy metal leadhumoral immunity deficiencyimmunogenimmunoglobulin heavy chain locusin vivolarge cell Diffuse non-Hodgkin's lymphomaleukemia/lymphomalymphoma/leukemiamouse modelmurine modelmutantmyelomamyelomatosisnoncodingpathwaypost-transcriptional gene regulationposttranscriptionalpreservationpreventpreventingrecruitresolutionssingle moleculesocial rolesomatic hypermutationsomatic variantsterilestudy designsuperresolution microscopytranscriptome sequencingtranscriptomic sequencing
Description preview
PROJECT SUMMARY
Background: VDJ recombination, Class switch recombination (CSR) and somatic hypermutation (SHM) are
three B lymphocyte specific processes that mediate antibody gene diversification. VDJ recombination requires
the DNA double strand generation by the Recombination activation genes (RAG1 and RAG2) whereas CSR and
SHM requires the…
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