grant
The role of mitochondrial glutathione homeostasis in tumor formation
Organization ROCKEFELLER UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025Active OxygenAddressAntioxidantsAssayAutoregulationBioassayBiochemicalBiological AssayBrainBrain Nervous SystemBreast CancerBreast Cancer CellBreast Cancer ModelBreast Cancer PatientBreast Cancer PreventionBreast MetastasisBreast NeoplasmsBreast Tumor PatientBreast TumorsBreast tumor modelCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessCytosolDependenceEncephalonEngineeringEnvironmentEnzyme GeneEnzymesExperimental GeneticsGEM modelGEMM modelGeneticGenetically Engineered MouseGlutathioneHomeostasisHumanIntermediary MetabolismIntracellular Communication and SignalingInvadedLinkLiposomalLiposomesLiverLungLung Respiratory SystemMaintenanceMalignant Breast NeoplasmMalignant CellMammary CancerMammary NeoplasmsMediatingMercaptansMercapto CompoundsMetabolicMetabolic ProcessesMetabolismMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LungMethodsMiceMice MammalsMitochondriaModern ManMolecularMurineMusMutation AnalysisNeoplasm MetastasisOncogenesisOrganOrganellesOxidation-ReductionOxygen RadicalsPDX modelPathway interactionsPatient derived xenograftPhysiological HomeostasisPro-OxidantsProductionPrognosisProteinsProteomicsPublishingReactive Oxygen SpeciesRedoxRegulationResistanceRoleSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSiteSourceSubcellular ProcessSulfhydryl CompoundsTestingTherapeuticThiolsTimeToxic effectToxicitiesWorkbiological signal transductionbreast cancer metastasisbreast cancer progressionbreast cancer survivalbreast tumor cellcancer cellcancer metastasiscancer progressioncancer typechemotherapeutic agentchemotherapeutic compoundschemotherapeutic drugschemotherapeutic medicationscolonization associated with lungcolonization in the lungcolonization within the lungexperimentexperimental researchexperimental studyexperimentsgamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycinegenetic approachgenetic strategygenetically engineered mouse modelgenetically engineered murine modelhepatic body systemhepatic organ systemin vivoindividuals with breast cancerinsightlung colonizationlung metastasismalignant breast tumormammary cancer modelmammary cancer preventionmammary tumormammary tumor modelmammary tumor preventionmetastasize to the lungmitochondrialmitochondrial membraneneoplasm progressionneoplastic progressionoxidation reduction reactionpathwaypatient derived xenograft modelpatients with breast cancerperson with breast cancerpressureprevent breast cancerpulmonary colonizationpulmonary metastasisresistantresponsesmall moleculesocial rolesulfhydryl grouptumortumor cell metastasistumor growthtumor progressiontumorigenesisuptake
Description preview
Project Summary
Cancer cells require substantial antioxidant capacity to overcome toxic effects of reactive oxygen species
(ROS). Despite their exclusive cytosolic production, cellular antioxidants are also abundantly present in
organelles, particularly in mitochondria. In particular, mitochondria, as the source of reactive oxygen species
(ROS),…
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