grant
The role of Kit signaling in taste bud regeneration
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 18 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAffectAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAppetiteAttentionAutoregulationBehavioral AssayBody Weight decreasedCancer CauseCancer DrugCancer EtiologyCancer PatientCancer TreatmentCancersCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCell SurvivalCell ViabilityCellsClinical TreatmentDataData SetDental HygieneDesire for foodDiet ModificationDietary ModificationsDistorted TasteDoseDrug TargetingDrug TherapyDrug usageDrugsDysfunctionDysgeusiaEatingEpitheliumExclusionFLT VEGF ReceptorFLT1 RTKFLT1 Receptor Tyrosine KinaseFlt-1Food IntakeFunctional disorderFutureGenesGustationHairHomeostasisHypomelanosisHypopigmentationImmunoblottingImpairmentIn VitroInterruptionIntracellular Communication and SignalingInvestigationKITLGKITLG geneKL-1Kidney CancerKidney CarcinomaKit Ligand GeneKitlLettersLifeLigandsLineage TracingMGF Stem Cell FactorMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalnutritionMast Cell Growth FactorMediatingMedicationMelaninsMental DepressionMetastatic Renal Cell CancerMetastatic Renal Cell CarcinomaMiceMice MammalsModalityMolecularMolecular GeneticsMurineMusNatural regenerationNeoplastic Disease Chemotherapeutic AgentsNerveNutritional DeficiencyOral HygieneOrganoidsPTK InhibitorsPTK ReceptorsParageusiaPatientsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysiological HomeostasisPhysiopathologyPilot ProjectsPrevalenceProductionProgenitor CellsProliferatingProtein Tyrosine Kinase InhibitorsProteinsProto-Oncogene Protein fltPublishingQOLQuality of lifeReceptor CellReceptor ProteinReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneReceptor Tyrosine Kinase,Class VRegenerationRenal CancerRenal CarcinomaReportingRoleSignal TransductionSignal Transduction SystemsSignalingSkinSodium ChlorideSteel FactorStem Cell FactorSurfaceTK InhibitorsTasteTaste Bud CellTaste BudsTaste PerceptionTestingTherapeutic UsesTongueTransmembrane Receptor Protein Tyrosine KinaseTumor-Specific Treatment AgentsTyrosine Kinase InhibitorTyrosine Kinase Linked ReceptorsTyrosine Kinase Receptor InhibitionTyrosine Kinase ReceptorsTyrosine Protein Kinase FRTTyrosine Protein Kinase Receptor FLTUndernutritionVEGF Receptor flt-1 ProteinVEGFR-1VEGFR1Vascular Endothelial Growth Factor Receptor-1VascularizationWeight LossWeight ReductionWestern BlottingWestern ImmunoblottingWorkadulthoodanti-cancer druganti-cancer therapybiological signal transductionbody weight lossc-kit Ligandcancer therapycancer-directed therapycell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular differentiationcellular lineage mappingcellular lineage trackingchemotherapyclinical interventionclinical therapydepressiondiet alterationdietary alterationdietary deficiencydrug interventiondrug treatmentdrug usedrug/agentexperiencefms-Like Tyrosine Kinasegustatory perceptiongustatory processinggustatory responsegustatory systemin vivokit Ligandleukodermamalignancymalnourishedneoplasm/cancernovelnutrition deficiencynutrition deficiency disordernutritional deficiency disorderparacrinepathophysiologypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspilot studyprotein blottingreceptorregeneratesaltsensory systemside effectsocial rolestem cellssweet tastesweet taste perceptiontaste processingtaste receptortaste responsetaste systemtranscriptome profilingtranscriptomic profilingtrendtrial regimentrial treatmenttumorwt-loss
Description preview
Cancer patients receiving most types of chemotherapy experience dysgeusia, i.e., distorted taste, which is
associated with depression, malnutrition, morbid weight loss, and interruption of life-prolonging treatment. Cells
within taste buds are continually and rapidly renewed, and this constant turnover makes taste prone to
disruption by cancer…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click