grant
The Role of Hypothalamic Dysfunction in Accelerating Aging in Humans
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 15 Aug 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202621+ years old65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAcarboseAccelerationActive Follow-upAddressAdultAdult HumanAgeAged 65 and OverAgingAnisotropyAquadiolAreaAssayAstrocytesAstrocytusAstrogliaAwardBioassayBiochemicalBiologicalBiological AgingBiological AssayBlood PlasmaBrainBrain Nervous SystemBrain imagingBrain regionChronic DiseaseChronic IllnessClinical DataCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDWI (diffusion weighted imaging)DWI-MRIDataData AnalysesData AnalysisDevelopmentDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDihydronorguaiaretic AcidDimenformonDiogynDiogynetsDiseaseDisorderDisturbance in cognitionDoctor of PhilosophyEncephalonEndocrine Gland SecretionEndocrinologyEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineFemaleFundingFutureGeneticGeriatricsGliosisGoalsGonadal HormonesHealthHormonalHormonesHortega cellHumanHypothalamic dysfunctionHypothalamic structureHypothalamusImageImpaired cognitionIncrease lifespanIntermediary MetabolismKnowledgeLeadLeadershipLength of LifeLifeLong-term cohort studyLongevityLongevity PathwayLongitudinal cohort studyMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMentorsMentorshipMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMetabolism and EndocrinologyMicrogliaModelingModern ManNMR ImagingNMR TomographyNeurocognitiveNeuroendocrineNeuroendocrine SystemNeurosecretory SystemsNordihydroguaiaretic AcidNuclear Magnetic Resonance ImagingOutcomeOvocyclinOvocylinParentsParticipantPartner in relationshipPb elementPersonalized medical approachPersonsPh.D.PhDPhenotypePlasmaPlasma SerumPositionPositioning AttributePreventative interventionPreventionProgynonProspective cohortProteinsProteomeRegulationResearchReticuloendothelial System, Serum, PlasmaRisk FactorsRodentRodentiaRodents MammalsRoleScientistStructureTestingTherapeutic EstradiolTherapeutic InterventionThesaurismosisTrainingVisitZeugmatographyabove age 65accelerated agingaccelerated biological ageaccelerated biological agingactive followupadult adiposityadult obesityadulthoodadults with obesityafter age 65age 65 and greaterage 65 and olderage 65 or olderageage accelerationage associated alterationsage associated changesage correlated alterationsage correlated changesage dependent alterationsage dependent changesage induced alterationsage induced changesage of 65 years onwardage related alterationsage related changesage specific alterationsage specific changesaged 65 and greateraged 65+aged ≥65agesaging associatedaging associated alterationsaging associated changesaging associated diseaseaging associated disordersaging correlated alterationsaging correlated changesaging delayaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging processaging relatedaging related alterationsaging related changesaging related diseaseaging related disordersaging resilienceaging specific alterationsaging specific changesalterations with ageanti aging based therapeuticanti aging therapeuticanti-aging property therapeuticastrocytic gliaattenuate agingbiologicbiological process of ageboost longevitybrain MR imagingbrain MRIbrain magnetic resonance imagingbrain visualizationcareercerebral MR imagingcerebral MRIcerebral magnetic resonance imagingchanges with agechronic disorderclinical investigationcognitive dysfunctioncognitive losscohortdMRIdata interpretationdecelerate agingdelay age relateddevelopmentaldiffusion tensor imagingdisabilitydisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingelongating the lifespanenhance longevityextend life spanextend lifespanextend longevityfollow upfollow-upfollowed upfollowupfoster longevityfrailtygeriatric medicinegeroscience therapeuticgerotherapeuticgitter cellhealthy aginghealthy human agingheavy metal Pbheavy metal leadhuman old age (65+)hypothalamicimagingimprove lifespanimprove longevityindexingindividualized approachinsightintervention for preventionintervention therapylife spanlifespanlifespan extensionmatemenmesogliametabolism disordermicroglial cellmicrogliocytemortalitymultidisciplinaryneural imagingneuro-imagingneuroimagingneurological imagingnoveloffspringolder adultolder adulthoodolder menolder womenover 65 yearsparentpause agingperivascular glial cellpersonalized approachpostpone age relatedprecision approachpreservationprevention interventionpreventional intervention strategypreventive interventionprolong lifespanprolong longevitypromote lifespanpromote longevityresilience during agingresilience in agingresilience in normal agingresilience to agingresilience with agingresilient agingresilient to agingresponseretards agingskillsslow agingslow down agingslow the rate of agingsocial rolesupport longevitytailored approachtherapeutic against agingtherapeutic interventions against agingtherapeutic strategies for agingtherapeutic strategies targeting agingtherapeutic target for anti-agingtherapeutic targeting agingtherapeutic targets to reverse agingtherapeutic to prevent agingtherapeutics impacts on agingtherapeutics that slow agingtranslational investigatortranslational researchertranslational scientist≥65 years♀
Description preview
The Role of Hypothalamic Dysfunction in Accelerating Human Aging
Sandra Aleksic, MD, M.S.
Mentor: Sofiya Milman, MD, M.S.
Co-mentors: Michael Lipton, MD, PhD; Joe Verghese, MBBS, MS
Abstract:
Mechanisms underpinning biological aging in humans remain incompletely understood. The hypothalamus
integrates key metabolic and neuroendocrine longevity…
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