grant
The role of hepatic Endoplasmic Reticulum architecture in metabolic homeostasis and disease
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 10 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Adult-Onset Diabetes MellitusAffectArchitectureAutoregulationBinding ProteinsBiochemicalBody TissuesCell BodyCellsDataDeteriorationDevelopmentDietDimensionsDiseaseDisorderDysfunctionEndoplasmic ReticulumEngineering / ArchitectureEquilibriumErgastoplasmEventFastingFatty LiverFunctional disorderGeneticGoalsGranular Endoplasmic ReticulumHealthHepaticHepatic CellsHepatic Parenchymal CellHepatocyteHomeostasisHumanImageImpairmentIncidenceIntegral Membrane ProteinIntrinsic Membrane ProteinKetosis-Resistant Diabetes MellitusLabelLeadLigand Binding ProteinLigand Binding Protein GeneLipidsLiverLiver CellsLiver SteatosisMAFLDMachine LearningMaturity-Onset Diabetes MellitusMembraneMetabolicMetabolic DiseasesMetabolic DisorderMetabolic dysfunctionMetabolic stressMiceMice MammalsMitochondriaModern ManMurineMusMutation AnalysisNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNutritionalObese MiceObesityOrganellesOutcomeOutputOvernutritionPathogenesisPb elementPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlayProcessProtein BindingProtein BiosynthesisProtein OverexpressionReceptor Down-RegulationRegulationResolutionRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomal ProteinsRiskRoleRough ERRough endoplasmic reticulumRough-Surfaced Endoplasmic ReticulumSiteSlow-Onset Diabetes MellitusSocietiesStable Diabetes MellitusStressStructureT2 DMT2DT2DMTestingThesaurismosisTissuesTransmembrane ProteinTransmembrane Protein GeneType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWorkadiposityadult onset diabetesbalancebalance functionbound proteinchronic hepatic diseasechronic hepatic disorderchronic liver diseasechronic liver disordercorpulencedevelopmentaldiet-associated obesitydiet-induced obesitydiet-related obesitydietsfastedfastsfat metabolismfatty acid oxidationfatty liver diseaseflexibilityflexiblefluorescence imagingfluorescent imaginggain of functionheavy metal Pbheavy metal leadhepatic body systemhepatic metabolismhepatic organ systemhepatic steatosishepatosteatosishuman tissueimagingimprovedin vivoketogenesisketosis resistant diabeteslipid metabolismliver metabolismloss of functionmRNA Translationmachine based learningmaturity onset diabetesmembrane structuremetabolic phenotypemetabolic-associated fatty liver diseasemetabolism disordermetabotypemitochondrialmouse modelmurine modelnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetnutritiousob/ob mouseobesity geneticsobesity interventionobesity therapyobesity treatmentoverexpressoverexpressionpathophysiologyprogramsprotein metabolismprotein synthesisreceptor bindingreceptor boundreceptor downregulationresolutionsresponsesocial roletype 2 DMtype II DMtype two diabetes
Description preview
ABSTRACT:
Metabolic dysfunction Associated Fatty Liver Disease (MAFLD) is the most common chronic liver disease, yet treatment options are limited. Within hepatocytes, the endoplasmic reticulum (ER) serves as a crucial hub for protein and lipid metabolism. Substantial evidence shows that dysfunction of hepatic ER, characterized by loss of its…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click