grant
The Role of Eosinophils in Modulating the Corneal Response to Infection
Organization WAYNE STATE UNIVERSITYLocation DETROIT, UNITED STATESPosted 1 Jul 2025Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AcuteAgeAllergyAnti-Bacterial AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsArray tomographyBALB C MouseBALB/cBacteriaBacterial InfectionsBehaviorBiologyBlindnessBlood EosinophilBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesC57BL/6 MouseCell BodyCell LocomotionCell MigrationCell MovementCellsCellular MigrationCellular MotilityChemotactic CytokinesChronicContact LensesCorneaCorneal DiseasesCorneal DisorderCorneal OpacityCorneal infectionDataDiseaseDisease OutcomeDisorderEosinophilic GranulocyteEosinophilic LeukocyteExhibitsEyeEyeballFibrosisFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGeographic AreaGeographic LocationsGeographic RegionGeographical LocationGram-Negative BacteriaGrowth AgentsGrowth FactorGrowth SubstancesHomologous Chemotactic CytokinesHumanImmuneImmune responseImmunesImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostInbred BALB C MiceIncidenceIndividualInfectionInfiltrationInflammationInflammatoryInflammatory ResponseInfluentialsIntercrinesKeratitisKnowledgeLeukomaLinkLiteratureMacrophageMarrow EosinophilMarrow NeutrophilMediatingMiceMice MammalsMicrobial keratitisMicroscopyMiscellaneous AntibioticModelingModern ManMurineMusMφNeutrophilic GranulocyteNeutrophilic LeukocyteP aeruginosaP. aeruginosaParasitic infectionPathogenesisPerforationPeripheralPersonsPhasePhenotypePhosphorylationPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPredispositionPrevalencePropertyProtein PhosphorylationProteins Growth FactorsProteomicsPseudomonas aeruginosaPseudomonas pyocyaneaResearch DesignResistanceResolutionRisk FactorsRoleSIS cytokinesStudy TypeSusceptibilityTestingTherapeuticTimeTissuesTraumaUlcerUlcerationWorkagesanti-bacterialbacteria infectionbacterial diseasecell motilitycellular targetingchemoattractant cytokinechemokinecomparativecornea disordercornea opacitycornealcorneal healingcorneal regenerationcytokineeosinophilexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygeographic sitehealinghost responsehypoimmunityimmune deficiencyimmune system responseimmunodeficiencyimmunoresponseimmunosuppressed patientimprovedin vivoin vivo Modelinfected with parasitesinfections in the corneainfectious keratitisinnovateinnovationinnovativeinsightmouse modelmurine modelneutrophilnovelocular surface diseaseocular surface disorderparasite infectionpathogenrecruitresistantresolutionsresponserestorationsocial rolespatial and temporalspatial temporalspatiotemporalspectral imagespectral imageryspectrographspectrum imagespectrum imagerystudy designtherapeutic targetvision lossvisual loss
Description preview
Project Summary/Abstract
Objective/Hypothesis: Pseudomonas aeruginosa is an opportunistic bacterium known to induce microbial
keratitis and is associated with rapid corneal destruction and blindness, especially in individuals who wear
contact lenses or are immunocompromised. Microbial keratitis triggers a robust inflammatory response driven
by the…
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