grant
The role of environmental enteric dysfunction in drug absorption and the pathogenesis of anemia among young children with pathogens affecting the gut
Organization RHODE ISLAND HOSPITALLocation PROVIDENCE, UNITED STATESPosted 16 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldA1PIAddressAdultAdult HumanAffectAgeAnemiaAnemia due to Chronic DisorderArea Under CurveBilharziaBilharziasisBindingBioavailabilityBiological AvailabilityBiological MarkersBlood CirculationBlood PlasmaBlood SerumBloodstreamBone MarrowBone Marrow Reticuloendothelial SystemChildChild YouthChildren (0-21)ClinicalDataDoseDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDrug KineticsDrugsDysfunctionEnteralEntericEpithelial CellsEquationFe elementFecesFosteringFunctional disorderFundingGeneralized GrowthGoalsGranulomaGranulomatous LesionGrowthGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHealthHepc peptideImmune Cell ActivationInfectionInflammationInflammation associated anemiaInflammatoryIntestinal AbsorptionIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal permeabilityInvestigatorsIronKilogramKnowledgeLMICLaboratoriesLaboratory ResearchLife CycleLife Cycle StagesMacrophageMalabsorption SyndromesMalnutritionMeasurementMeasuresMediatingMedicationMentorsModelingMolecular InteractionMorbidityMorbidity - disease rateMφNational Institutes of HealthNutritional DeficiencyOlder PopulationOralPathogenesisPathway interactionsPersonsPharmaceutical PreparationsPharmacokineticsPharmacologyPhysiologic AvailabilityPhysiopathologyPlasmaPlasma SerumPrasiquantelPraziquantelProcessProductionRandomizedRandomized, Controlled TrialsResearchResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRibosomal DNARoleSamplingSchistosomaSchistosomeSchistosomiasisSerumSmall IntestinesTechniquesTherapeuticTimeTissue GrowthUgandaUndernutritionUnited States National Institutes of HealthUpregulationVillous AtrophyVillous Bluntingabsorptionadulthoodage groupagedagesalpha 1 Antiproteasealpha 1-Antiproteinasealpha 1-Antitrypsinalpha 1-Antitrypsin Trypsin Inhibitoralpha 1-Protease Inhibitoralpha 1-Proteinase Inhibitoranemia of chronic diseaseanemia of inflammationbio-markersbiologic markerbiomarkerbowel inflammationcohortdietary deficiencydrug/agenteggferroportinferroportin1 proteingastrointestinal absorptiongastrointestinal absorption disordergut inflammationhepcidinhigh riskhuman pathogenimmune activationinflamed bowelinflamed gutinflamed intestineinternational centerintestinal barrierintestinal epitheliumintestinal inflammationintestinal malabsorptionintestinal mucosal barrierkidslife courselow and middle-income countriesmalabsorptionmalnourishedmetal transporting protein 1microbialmicrobial productsnew markernovelnovel biomarkernovel markernutrition deficiencynutrition deficiency disordernutritional deficiency disorderolder groupsolder individualsolder personontogenyoral vaccinepathogenpathophysiologypathwaypharmacokinetic modelrDNArandomisationrandomizationrandomized control trialrandomly assignedsmall bowelsocial rolesolute carrier family 40 (iron-regulated transporter), member 1stoolsystemic inflammationsystemic inflammatory responsetranslation strategytranslational approachtranslational strategyuptakevaccine efficacyyoungsterα1-Antitrypsinα1-Proteinase Inhibitor
Description preview
PROJECT SUMMARY .
Schistosomiasis causes significant morbidity in the gut as eggs traverse the intestinal barrier, disrupting the
integrity of the small intestine wall. In this way, schistosomiasis contributes to environmental enteric dysfunction
(EED), a common condition in low- and middle-income countries that is characterized by small…
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