grant

The role of ECM-mediated mechanosignaling on regional immunosuppression in GBM

Organization UNIVERSITY OF LOUISVILLELocation LOUISVILLE, UNITED STATESPosted 1 Feb 2020Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AddressAffectAtomic Force MicroscopyAutomobile DrivingB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BehaviorBiophysicsBlood monocyteBody TissuesCD44CD44 geneCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOBRECTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCancer CenterCancersCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCell surfaceCell-Extracellular MatrixCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessCenter of Biomedical Research ExcellenceCenters of Research ExcellenceCheckpoint inhibitorCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDataDevelopmentDifferentiation in cell cultureECMEpitheliumExtracellular MatrixForce MicroscopyGene TranscriptionGenetic TranscriptionGlioblastomaGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHPGFHepatocyte-Stimulating FactorHumanHyaluronic AcidHybridoma Growth FactorHydrogelsIFN-beta 2IFNB2IL-17IL-17 GeneIL-17AIL-17A GeneIL-6IL17IL17 ProteinIL17 geneIL17AIL17A GeneIL6 ProteinImmuneImmune checkpoint inhibitorImmune mediated therapyImmunesImmunityImmunocompetentImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyImplantIn VitroIn vitro cell differentiationInfiltrationInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17Interleukin-6Intracellular Communication and SignalingLesionLinkMDU3MGI-2MalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMapsMarrow monocyteMechanicsMediatingMesenchymalMesenchymal DifferentiationMiceMice MammalsModelingModern ManMurineMusMyeloid CellsMyeloid Differentiation-Inducing ProteinMyeloid-derived suppressor cellsOutcomePathway interactionsPatientsPatternPgp1PhasePhenotypePlasmacytoma Growth FactorPrimary Brain NeoplasmsPrimary Brain TumorsPublishingRNA ExpressionReceptor ProteinRefractoryRegulationReportingRoleSTAT3STAT3 geneSamplingScanning Force MicroscopySchemeSignal TransductionSignal Transduction SystemsSignalingSolidStaining methodStainsStrains Cell LinesSubcellular ProcessT-CellsT-LymphocyteT8 CellsT8 LymphocytesTestingTissuesTranscriptionanti-cancer immunotherapyanti-tumor immune responseanticancer immunotherapybiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescancer immunologycancer immunotherapycancer microenvironmentcellular differentiationcultured cell linecytokinedevelopmentaldifferentiation in culturedifferentiation in vitrodrivingeffective therapyeffective treatmentglioblastoma multiformeimmune check point inhibitorimmune competentimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive myeloid cellsimmunosuppressive responseimmunotherapy for cancerimmunotherapy of cancerin vitro cellular differentiationin vivoinsightinterferon beta 2malignancymechanicmechanicalmonocytemyeloid suppressor cellsmyeloid-derived suppressive cellsneoplasm immunologyneoplasm/cancernoveloverexpressoverexpressionpathwayprogramsreceptorrecruitsocial rolespongioblastoma multiformesuppressive myeloid cellsthymus derived lymphocytetranscriptomicstransplant modeltumortumor immunologytumor microenvironment
Sign up free to applyApply link · pipeline · email alerts
— or —

Get email alerts for similar roles

Weekly digest · no password needed · unsubscribe any time

Description preview

PROJECT SUMMARY (PROJECT 3 – CHEN)
“The role of ECM-mediated mechanosignaling on regional immunosuppression in GBM”
Recent studies reveal that immunosuppressive regions vary substantially throughout the heterogeneous
glioblastoma (GBM) tumor microenvironment. These immune-restricted niches appear to correspond to specific
extracellular matrix…

🔒

Full details available on the Agency plan

Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.

Start 7-day free trial — $29.99/mo →

Agency Plan

7-day free trial

Unlock procurement & grants

Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.

$29.99 / month

  • 🔔Email alerts for new matching tenders
  • 🗂️Track tenders in your pipeline
  • 💰Filter by contract value
  • 📥Export results to CSV
  • 📌Save searches with one click
Start 7-day free trial →

Explore more

📍 More grants in UNITED STATES🏷 More NIH opportunities🏷 More US Federal opportunities🏷 More Research Grant opportunities🏢 All nih_reporter opportunities
The role of ECM-mediated mechanosignaling on regional immunosuppression in GBM — UNIVERSITY OF LOUISVILLE | UNITED STATE | Dev Procure