grant
The Role of Dendritic Cells in Regulating the Gut-Brain Immune Axis in Ischemic Stroke
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026Acquired brain injuryAcuteAffectApoplexyB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Body TissuesBone-Derived Transforming Growth FactorBrainBrain InjuriesBrain IschemiaBrain Nervous SystemBrain Vascular AccidentCD11cCD126 AntigensCD126 ReceptorCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCause of DeathCell BodyCell Communication and SignalingCell SignalingCellsCerebral IschemiaCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeClinical TrialsCo-cultureCocultivationCocultureCoculture TechniquesDendritic CellsDevelopmentDietary InterventionDiseaseDisorderDysfunctionEncephalonEpitheliumEquilibriumFunctional disorderGI commensalGI microbiotaGamma-delta T cellsGastrointestinal microbiotaGoalsHPGFHepatocyte-Stimulating FactorHistologicHistologicallyHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL-6 ReceptorsIL6 ProteinIL6 ReceptorsITGAXITGAX geneImmuneImmune RegulatorsImmune infiltratesImmune responseImmune systemImmunesImmunityImmunomodulationImmunomodulatorsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn VitroInflammationInflammatoryInflammatory ResponseInnate ImmunityInterleukin 6 ReceptorInterleukin-6InterphaseIntestinalIntestinal ContentIntestinesIntracellular Communication and SignalingIschemiaIschemic Brain InjuryIschemic EncephalopathyIschemic StrokeLymphatic cellLymphocyteLymphocyticMGI-2MaintenanceMediatingMediatorMeningesMiceMice MammalsMilk Growth FactorModelingModern ManMolecularMolecular TargetMorbidityMurineMusMyeloid Differentiation-Inducing ProteinNative ImmunityNatural ImmunityNeurologic outcomeNeurological outcomeNon-Specific ImmunityNonspecific ImmunityNutrition InterventionsNutritional InterventionsPathologic ProcessesPathological ProcessesPathologyPathway interactionsPeripheralPhenotypePhysiopathologyPlasmacytoma Growth FactorPlatelet Transforming Growth FactorPlayPopulationPreventiveProbioticsReceptor ProteinRegulatory T-LymphocyteReporterResearchRodentRodentiaRodents MammalsRoleRouteShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall IntestinesStrokeStroke preventionSurfaceT cell differentiationT-CellsT-LymphocyteT4 CellsT4 LymphocytesTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeuticTherapeutic InterventionTissuesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransmissionTregVeiled Cellsadaptive immunityafter strokebacteria in the gutbalancebalance functionbiological signal transductionbowelbrain attackbrain cellbrain damagebrain-injuredcellular targetingcerebral ischemic damagecerebral ischemic injurycerebral vascular accidentcerebrovascular accidentcommensal bacteriacommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecommensal bacterial speciescommensal floracommensal microbescommensal microbiotacommensal microfloradevelopmentaldiet interventiondisabilityenteric commensalenteric microbial communityenteric microbiotagastrointestinal commensalgastrointestinal microbial floragut bacteriagut commensalgut communitygut floragut microbe communitygut microbesgut microbial communitygut microbial compositiongut microbial consortiagut microbial speciesgut microbiotagut microbioticgut microflorahost responseimmune cell infiltrateimmune modulationimmune modulatorsimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunologic reactivity controlimmunological statusimmunomodulatoryimmunomodulatory moleculesimmunoregulationimmunoregulatorimmunoregulatoryimmunoregulatory moleculesimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivo Modelinfection riskinjury to tissueinterferon beta 2intervention therapyintestinal commensalintestinal floraintestinal microbesintestinal microbiotaintestinal microfloraintestinal tract microfloraischemia injuryischemic brain damageischemic injurylymph celllymph organlymphatic organlymphoid organmeningemicrobialmicrobial compositionmicrobial consortiamicrobial floramicrobiomemicrobiotamicrobiota-gut-brain axismicrobiota-gut-brain interactionsmicrobiota-gut-brain signalingmicrofloramouse modelmultispecies consortiamurine modelneuroprotectionneuroprotectivenew approachesnovel approachesnovel strategiesnovel strategypathophysiologypathwaypost strokepoststrokeprevent strokeprogramsreceptorrecruitregulatory T-cellsrepairrepairedrisk for strokerisk of strokesmall bowelsocial rolestroke outcomestroke patientstroke riskstroke therapystroke treatmentstrokedstrokessuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutically effectivethymus derived lymphocytetissue injurytraffickingtransmission processtreating strokeγδ T cellsγδT cells
Description preview
Project Summary/Abstract
Stroke is a prevalent and devastating disease with limited therapeutic options. Inflammation and
immune cells are major components in the pathophysiology of ischemic stroke and contribute to acute
and delayed tissue injury. However, our incomplete understanding of the factors regulating the immune
responses triggered by…
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