grant
The role of collisions in rescuing stalled ribosomes in bacteria
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 15 Feb 2021Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY202610Sa RNAATP HydrolysisATP phosphohydrolaseATPaseAddressAdenosine TriphosphataseAntibiotic AgentsAntibiotic DrugsAntibioticsB subtilisB. subtilisBacillus subtilisBackBacteriaBacterial GenomeBindingBiochemicalCell BodyCellsChemicalsClinicalCollaborationsComplexCryo-electron MicroscopyCryoelectron MicroscopyDNA HelicasesDNA Unwinding ProteinsDNA unwinding enzymeDNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDataDorsumE coliE. coliElectron CryomicroscopyEscherichia coliEukaryotaEukaryoteEventFundingGeneHomologGoalsHomologHomologous GeneHomologueIn VitroKinasesKineticsL-ProlineLeadLearningMeasuresMessenger RNAMethodsMiscellaneous AntibioticMolecularMolecular InteractionNamesPathway interactionsPb elementPhosphorylationPhosphotransferase GenePhosphotransferasesPlayProbabilityProductivityProlineProtein BiosynthesisProtein PhosphorylationProtein Synthesis InhibitionProteinsQualifyingQuality ControlRNA PolymerasesRecyclingResistanceRibo-seqRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomesRoleSignal PathwaySiteSsrAStop CodonStructureSystemTermination CodonTerminator CodonTestingTranscriptTranslatingTranslation Stop SignalTranslationsTransphosphorylasesWorkcryo-EMcryoEMcryogenic electron microscopyexperimentexperimental researchexperimental studyexperimentsgenetic selectionglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadhelicasehigh definitionhigh-resolutionin vivomRNAmRNA DecaymRNA DegradationmRNA Transcript Degradationnamenamednamingnovelnucleasepathwaypreventpreventingprotein synthesisreconstitutereconstitutionresistantribosome footprint profilingribosome profilingsocial rolessrA gene producttmRNAtranscriptometransfer-messenger RNAtranslation
Description preview
PROJECT SUMMARY
Translating ribosomes often encounter obstacles that stop them in their tracks. Ribosome quality
control (RQC) pathways remove stalled ribosomes from mRNA so that they can be recycled. In the
absence of RQC, bacteria are hypersensitive to many clinically important antibiotics that target the
ribosome. The goal of this proposal is…
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