grant
The Role of CD4+ Memory T cell Subtypes in Periodontal Disease Recurrence
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY202516S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seq21+ years oldAccelerationAcuteAdultAdult HumanAlveolar Bone LossAlveolar ResorptionAntigensApoptosisApoptosis PathwayAssayAwardBacteriaBioassayBiological AssayBirthBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8BCD8B1CD8B1 geneCell BodyCell CompartmentationCell CompartmentationsCellsCervical Lymph NodeCervical lymph node groupChronic DiseaseChronic IllnessChronic PeriodontitisClinicalComplexDataDevelopmentDiseaseDisease ProgressionDisorderDown-RegulationFosteringFutureGeneralized GrowthGenerationsGerm-FreeGingivaGingivalGoalsGrowthGum DiseaseHealthHealth TransitionHumanImmuneImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologyInflammationInflammatoryIntervention StrategiesInvestigatorsKnowledgeLYT3LifeLigatureLinkLiteratureLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesMemoryMetabolicMethodsMiceMice MammalsModelingModern ManMouth microbiomeMucosaMucosal TissueMucous MembraneMurineMusNIDCRNIDRNational Institute of Dental ResearchNational Institute of Dental and Craniofacial ResearchOralOral CharactersParodontosisParturitionPathogenicityPathologicPatientsPeriodontal Bone LossPeriodontal DiseasesPeriodontal ResorptionPeriodontitisPhasePhenotypePopulationPostdocPostdoctoral FellowPre-Clinical ModelPreclinical ModelsProcessProductivityProgrammed Cell DeathPropertyPublic HealthRecurrenceRecurrentRecurrent diseaseRegulatory T-LymphocyteRelapseRelapsed DiseaseResearchResearch AssociateResearch PersonnelResearchersResolutionRoleT cell infiltrationT memory cellT-CellsT-LymphocyteT4 CellsT4 LymphocytesTeff cellTestingTherapeuticTimeTissue ExpansionTissue GrowthTissuesTooth LossTregadulthoodbonebone losscareercell typecheck point inhibitioncheckpoint inhibitionchronic disorderchronic inflammatory diseaseclinical relevanceclinically relevantdevelopmentaldisease modeldisorder modeleffector T cellgerm free conditionhealthy aginghealthy human agingimmune check point inhibitionimmune checkpoint inhibitionimmunogenin vivo Modelinflammatory bone losslymph glandlymph nodeslymphnodesmemory CD4 T cellmemory CD4 T lymphocytememory T lymphocytemicrobialmicrobial antigenmicrobial colonizationmicroorganism antigenmouse modelmurine modelnovelontogenyoral microbiomeperiodontal disorderperiodontium diseaseperiodontium disorderpost-docpost-doctoralpost-doctoral traineepreventpreventingprogramsregulatory T-cellsresearch associatesresolutionsresponsesocial rolespatial and temporalspatial temporalspatiotemporalspecific pathogen freetherapeutic targetthymus derived lymphocytetranscriptomicstranslational investigatortranslational researchertranslational scientisttranslational study
Description preview
Project Summary
The recurrence of periodontal disease (PD) is a poorly immunologically defined or therapeutically targeted
clinical challenge. Uncovering the homeostatic and pathogenic potential of long-term immune cells in
periodontal tissues is crucial to revealing the cellular drivers of PD recurrence. This proposal focuses on
an overlooked…
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