grant
The Role of CD3z ITAM (Immunoreceptor Tyrosine-Based Activation Motif) diversity in CAR T cell Force and Function
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 3 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20252-dimensional70 kDa zeta-associated proteinARAMAdoptive TransferAffinityAg Recognition Activation MotifAntigen TargetingAntigenic DeterminantsAntigensB cell malignancyB lymphoid malignancyBindingBinding DeterminantsBiologyCAR T cellsCAR modified T cellsCAR-TCAR-TsCD19CD19 geneCD28CD28 geneCD3CD3 AntigensCD3 ComplexCD3 moleculeCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCalibrationCancersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular MatrixCellular PhysiologyCellular ProcessClinicalCytoskeletal SystemCytoskeletonDataEpitopesEventExhibitsFailureGenerationsGoalsGrantHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHumanITAMImmune Cell ActivationImmunoreceptor Tyr-Based Activation MotifImmunoreceptor Tyrosine-Based Activation MotifIn VitroIndividualInfiltrationIntracellular Communication and SignalingKinasesKineticsLigandsMHC InteractionMHC ReceptorMajor Histocompatibility Complex ReceptorMalignant Hematologic NeoplasmMalignant NeoplasmsMalignant TumorMeasuresMembraneMemoryMiceMice MammalsModern ManMolecular InteractionMurineMusOKT3 antigenPatientsPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeptidesPhasePhenotypePhosphoproteinsPhosphorylationPhosphotransferase GenePhosphotransferasesPositionPositioning AttributeProductionProliferatingProtein PhosphorylationProtein Tyrosine Kinase Zap70ProteinsPublishingReceptor ActivationReceptor ProteinReceptor SignalingRoleSRKSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpecificityStimulusSubcellular ProcessSyk-related tyrosine kinaseT cell receptor based immunotherapyT cell receptor cellular immunotherapyT cell receptor engineered therapyT cell receptor immunotherapyT cells for CART memory cellT-Cell Antigen ReceptorsT-Cell DevelopmentT-Cell OntogenyT-Cell ProliferationT-Cell ReceptorT-Cell Receptor TherapyT-Cell Receptor TreatmentT-Cell Receptor based TherapyT-Cell Receptor based TreatmentT-CellsT-LymphocyteT-Lymphocyte DevelopmentT3 AntigensT3 ComplexT3 moleculeT44T8 CellsT8 LymphocytesTCR T cell immunotherapyTCR T cell therapyTCR TherapyTCR based T cell immunotherapyTCR based TherapyTCR based immune therapyTCR based immunotherapyTCR based treatmentTCR immunotherapyTeff cellTestingToxic effectToxicitiesTransphosphorylasesTumor CellTyrosineWorkZAP-70ZAP-70 GeneZAP-70 KinaseZAP-70 proteinZAP70Zeta-Chain Associated Protein Kinasebiological signal transductionchimeric antigen T cell receptorchimeric antigen receptorchimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cellschimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellscytokinecytokine release syndromecytokine stormdesigndesigningeffector T cellextracellularfightingfitnessimmune activationimmunogenimprovedin vivoinsightinterestintracellular skeletonmalignancymembrane structurememory T lymphocytemouse modelmurine modelmutantneoplasm/cancerneoplastic cellneuron toxicityneuronal toxicityneurotoxicitynovelpMHCphospho-proteomicsphosphoproteomicsreceptorreceptor functionrecruitresponsesocial rolethymus derived lymphocytetumortwo-dimensional
Description preview
Chimeric Antigen Receptors (CARs) are a combination of an extracellular single-chain variable fragment region
(scFV) that recognizes tumor protein antigens in an MHC independent manner and an intracellular region that
transduces extracellular stimuli similar to T Cell Receptor (TCR) signaling. Optimization of CAR constructs is of
high importance…
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