grant
The Role of Annexin A1 Expression in Glioblastoma-Associated Astrocytes
Organization VA BOSTON HEALTH CARE SYSTEMLocation BOSTON, UNITED STATESPosted 1 Jan 2026Deadline 31 Dec 2029
VANIHUS FederalResearch GrantFY2026Annexin A1Annexin IArmed Forces PersonnelAstrocytesAstrocytusAstrogliaAutopsyBar CodesBiologyBoard CertificationBody TissuesBostonBrainBrain CancerBrain MetastasisBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TraumaBrain TumorsCalpactin IICancer CauseCancer EtiologyCancersCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCessation of lifeChemoattractant ReceptorChemotactic Peptide ReceptorChromobindin 9ClinicalClinical DataCo-cultureCocultivationCocultureCoculture TechniquesComplementComplement ProteinsDataDeathDetectionDevelopmentDoctor of PhilosophyDysfunctionEncephalonEnvironmental ExposureEnvironmental ToxinExposure toF-Chemotactic Peptide ReceptorFMLP ReceptorFPR1FPR1 geneFormyl Peptide Receptor 1Formyl Peptide ReceptorsFunctional disorderGene InactivationGene SilencingGeneral PopulationGeneral PublicGeneralized GrowthGenesGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrowthHistologyHortega cellHumanImmuneImmune TargetingImmune mediated therapyImmune responseImmune systemImmunesImmunityImmunofluorescenceImmunofluorescence ImmunologicImmunofluorescence MicroscopyImmunoglobulin Enhancer-Binding ProteinImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyIncidenceInflammasomeInflammatoryIntracellular Communication and SignalingInvestigatorsKinasesLigandsLinkLipocortin 1Lipocortin IMacrophageMalignant CellMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMeasuresMediatorMedical centerMetastatic Neoplasm to the BrainMetastatic Tumor to the BrainMetastatic malignant neoplasm to brainMiceMice MammalsMicrogliaMilitaryMilitary PersonnelModelingModern ManMolecularMolecular TargetMurineMusMφN-Formylmethionyl Peptide ReceptorN-Formylpeptide ReceptorN-formyl Hexapeptide ReceptorNF-kBNF-kappa BNF-kappaBNFKBNeuroglial NeoplasmNeuroglial TumorNeurologistNeurosciencesNewly DiagnosedNon-MalignantNuclear Factor kappa BNuclear Transcription Factor NF-kBOncologistOperative ProceduresOperative Surgical ProceduresOutcomePD-1 antibodyPD1 antibodyPathway interactionsPatientsPh.D.PhDPhenotypePhosphotransferase GenePhosphotransferasesPhysiopathologyPrognosisProteinsQOLQuality of lifeReceptor ProteinRecombinant Oncostatin MRecurrenceRecurrentRegulationRenocortinResearchResearch PersonnelResearch SpecimenResearchersRoleSignal TransductionSignal Transduction SystemsSignalingSiteSpecimenStaining methodStainsSurgicalSurgical InterventionsSurgical ProcedureSurvival AnalysesSurvival AnalysisT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell responseT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyTCGATechniquesTestingThe Cancer Genome AtlasTherapeuticTissue GrowthTissuesToxic Environmental AgentsToxic Environmental SubstancesToxinTrainingTranscription Factor NF-kBTransphosphorylasesTraumatic Brain InjuryTumor CellTumor-associated macrophagesVaccinesVeteransaPD-1aPD1active dutyactive serviceadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyanti programmed cell death 1anti-PD-1anti-PD-1 Abanti-PD-1 antibodiesanti-PD-1 monoclonal antibodiesanti-PD1anti-PD1 Abanti-PD1 antibodiesanti-PD1 monoclonal antibodiesanti-programmed cell death protein 1anti-programmed cell death protein 1 antibodiesanti-programmed death-1 antibodyantiPD-1astrocytic gliabarcodebarcode analysis by retrograde rabiesbarcoded rabiesbiological signal transductionbrain cellbrain micrometastasiscancer cellcancer microenvironmentcancer typecell typecheck point blockadecheckpoint blockadeclinical practiceclinical relevanceclinical validationclinically relevantcomplementationdevelopmentalenvironmental toxicantexperimentexperimental researchexperimental studyexperimentsexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfMet-Leu-Phe receptorgitter cellglial-derived tumorglioblastoma multiformehost responseimmune check point blockadeimmune checkpoint blockadeimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenic apoptosisimmunogenic cell deathimmunoresponseimmunosuppressedimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedkappa B Enhancer Binding Proteinknock-downknockdownmalignancymesogliamicroglial cellmicrogliocytemilitary populationmouse modelmurine modelnecropsyneoplasm/cancerneoplastic cellneural inflammationneuro-oncologyneuroglia neoplasmneuroglia tumorneuroinflammationneuroinflammatoryneurooncologynew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnonmalignantnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetnuclear factor kappa betaoncostatin Montogenypathophysiologypathwayperivascular glial cellpostmortempre-clinicalpreclinicalprogramsrabies virus barcodingreceptorresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolespongioblastoma multiformesurgerytherapeutic T-cell platformthymus derived lymphocytetooltranscriptional silencingtraumatic brain damagetumortumor growthtumor microenvironmenttumors in the brainαPD-1αPD1
Description preview
Astrocytes profoundly influence immunity, but they are negligibly characterized in glioblastoma (GBM). My
preliminary data suggest that GBM-associated astrocytes expressing annexin A1 (ANXA1) contribute to
immunosuppression in GBM: 1) ANXA1 expression in non-malignant astrocytes is correlated with early GBM
recurrence and inversely correlated with…
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