grant
The role of adipocyte-drive inflammation and leptin pathway in pulmonary viral infections caused by SARS-CoV-2 and influenza A viruses
Organization LOUISIANA STATE UNIV A&M COL BATON ROUGELocation BATON ROUGE, UNITED STATESPosted 2 Jan 2019Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAcuteAdipocytesAdipose CellAdult-Onset Diabetes MellitusAffectAirAlveolarAutomobile DrivingBiologic ModelsBiologicalBiological ModelsBiologyCOVID-19 virusCOVID19 virusCell BodyCell Communication and SignalingCell SignalingCellsCellular injuryChronicClinicalCoV-2CoV2ComplexConditioned Culture MediaConditioned MediumDevelopmentDiseaseDisease OutcomeDisorderDissectionElementsEpitheliumExposure toFat CellsFutureGeneral PopulationGeneral PublicGoalsGroups at riskH1N1H1N1 VirusHuB219HumanImmuneImmune responseImmunesImpairmentIn VitroIndividualInfectionInflammationInflammatory ResponseInfluentialsInfluenza AInfluenza A Virus, H1N1 SubtypeInfluenza A virusInfluenza Viruses Type AInfluenzavirus AIntensive CareInterventionIntervention StrategiesIntracellular Communication and SignalingKetosis-Resistant Diabetes MellitusKnowledgeLEP-RLEPR ProteinLeptinLeptin resistanceLifeLipocytesLiquid substanceLungLung Alveolar EpitheliaLung DiseasesLung ParenchymaLung Respiratory SystemLung TissueLung damageMacrophageMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMetabolicMetabolic DiseasesMetabolic DisorderMiceMice MammalsModel SystemModelingModern ManMorbid ObesityMorbidityMorbidity - disease rateMurineMusMφNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusOB ReceptorOB-ROb Gene ProductOb ProteinObese Gene ProductObese ProteinObesityOrthomyxovirus Type AOutcomeOver weightOverweightPathogenesisPathogenicityPathway interactionsPatientsPeople at riskPersonsPersons at riskPopulationPopulations at RiskPredispositionPrevalencePublic HealthPulmonary DiseasesPulmonary DisorderReceptor SignalingResearchRespiratory EpitheliumRiskRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2STAT3STAT3 geneSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Severe obesityShapesShort interfering RNASignal PathwaySignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSmall Interfering RNAStable Diabetes MellitusStructure of parenchyma of lungStructure of respiratory epitheliumSusceptibilityT2 DMT2DT2DMTestingTherapeuticTherapeutic InterventionThesaurismosisType 2 Diabetes MellitusType 2 diabetesType A InfluenzaType II Diabetes MellitusType II diabetesViralViral DiseasesViral Respiratory Tract InfectionVirus DiseasesVirus ReplicationWorkWuhan coronavirusadiposityadult onset diabetesairway epitheliumalveolar epitheliumbiologicbiological signal transductioncell damagecell injurycellular damageclinical relevanceclinically relevantco-morbidco-morbiditycombatcomorbiditycoronavirus disease 2019 viruscoronavirus disease-19 viruscorpulencedamage to cellsdefined contributiondevelopmentaldiabeticdisease of the lungdisorder of the lungdrivingevidence baseextreme obesityflu infectionflu virus infectionfluidhCoV19high riskhost responseimmune system responseimmunoresponsein vivoinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfection riskinfluenza infectioninfluenza virus infectioninjury to cellsinnovateinnovationinnovativeintervention therapyketosis resistant diabetesleptin receptorleptin-binding proteinliquidlung disorderlung functionlung injurymaturity onset diabetesmetabolism disordermortalitymouse modelmurine modelmutantnCoV2new therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachobese individualsobese peopleobese personobese populationobese subjectspandemicpandemic diseasepathwaypermissivenesspulmonarypulmonary damagepulmonary functionpulmonary injurypulmonary tissue damagepulmonary tissue injuryrespiratory tract epitheliumrespiratory virusresponsesiRNAsocial roletherapeutically effectivetissue culturetooltype 2 DMtype II DMtype two diabetesviral infectionviral multiplicationviral replicationviral respiratory infectionvirus infectionvirus multiplicationvirus-induced disease
Description preview
The “obesity pandemic” is a major global public health issue that affects more than 40% of the US population and is tightly interrelated with type 2 diabetes mellitus (T2DM). Obese subjects are at least 3 times more likely to develop critical and life-threatening respiratory viral infections like that of Influenza A. A large proportion of the…
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