grant
The Role of ADAM9 in the Innate Immune Response to SARS-CoV-2 Infection
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 26 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV S protein2019-nCoV spike glycoprotein2019-nCoV spike proteinACE2ARDSAcute Lung InjuryAcute Pulmonary InjuryAcute Respiratory DistressAcute Respiratory Distress SyndromeAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAntibodiesAssayB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BindingBioassayBiochemicalBiological AssayBody TissuesBronchoalveolar Lavage FluidCOVID infected patientCOVID patientCOVID positive patientCOVID-19COVID-19 S proteinCOVID-19 infected patientCOVID-19 infectionCOVID-19 patientCOVID-19 positive patientCOVID-19 spikeCOVID-19 spike glycoproteinCOVID-19 spike proteinCOVID-19 virusCOVID-19 virus infectionCOVID19 infectionCOVID19 patientCOVID19 positive patientCOVID19 virusCV-19Cell BodyCell Communication and SignalingCell SignalingCellsCessation of lifeClinicalCoV-2CoV2Coronavirus Infectious Disease 2019Critical IllnessCritically IllDa Nang LungDataData AnalysesData AnalysisDeathDeath RateDevelopmentDiseaseDisintegrinsDisorderDouble-Stranded RNAELISAEMC virusEMCVEncephalomyocarditis virusEndogenous Interferon BetaEnsureEnzyme-Linked Immunosorbent AssayExperimental DesignsFibroblast InterferonFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoundationsGene ExpressionGene TranscriptionGenesGenetic TranscriptionGoalsGrantHPGFHepatocyte-Stimulating FactorHumanHuman Cell LineHybridoma Growth FactorIFIH1IFNIFN-beta 2IFN-βIFNB2IFNbIL-6IL6 ProteinImmuneImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune RegulatorsImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune infiltratesImmune responseImmunesImmunityImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunomodulatorsInfectionInfiltrationInflammationInflammatoryInflammatory ResponseInnate Immune ResponseInnate ImmunityInstitutionInterferon Induced With Helicase C Domain 1Interferon Type IInterferon-βInterferonsInterleukin-6Intracellular Communication and SignalingInvestigationInvestigatorsKO miceKineticsKnock-out MiceKnockout MiceLengthLentiviral VectorLentivirus VectorLuciferase ImmunologicLuciferasesLungLung ParenchymaLung Respiratory SystemLung TissueMDA 5MGI-2MOF syndromeManuscriptsMediatingMengo VirusMengovirusMentorsMentorshipMetallopeptidasesMetalloproteasesMetalloproteinasesMiceMice MammalsModern ManMolecular InteractionMultiple Organ Dysfunction SyndromeMultiple Organ FailureMurineMusMutateMyeloid Differentiation-Inducing ProteinNative ImmunityNatural ImmunityNatural Interferon BetaNatural human interferon betaNon-Polyadenylated RNANon-Specific ImmunityNonspecific ImmunityNull MousePathogenesisPathologicPathologyPathway interactionsPatientsPlaque AssayPlasmacytoma Growth FactorPlayPostdocPostdoctoral FellowPreparationProcessProductionProteinsPublishingPulmonary PathologyRNARNA ExpressionRNA Gene ProductsResearchResearch AssociateResearch PersonnelResearchersRibonucleic AcidRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 SSARS-CoV-2 S proteinSARS-CoV-2 infected patientSARS-CoV-2 infectionSARS-CoV-2 pathogenesisSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV-2 spikeSARS-CoV-2 spike glycoproteinSARS-CoV-2 spike proteinSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 S proteinSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 spike glycoproteinSevere acute respiratory syndrome coronavirus 2 spike proteinSevere acute respiratory syndrome related corona virus 2SeveritiesSeverity of illnessShock LungSignal TransductionSignal Transduction SystemsSignalingStaining methodStainsStiff lungStructure of parenchyma of lungSyndromeTestingTimeTissuesTrainingTranscriptionTransfectionTransgenesVascular PermeabilitiesViralViral BurdenViral DiseasesViral Gene ProductsViral Gene ProteinsViral GenomeViral LoadViral Load resultViral PathogenesisViral ProteinsVirionVirusVirus DiseasesVirus ParticleVirus ReplicationWuhan coronavirusangiotensin converting enzyme 2angiotensin converting enzyme IIantagonismantagonistbiological signal transductioncareer developmentcell transductioncellular transductioncofactorcoronavirus disease 2019coronavirus disease 2019 S proteincoronavirus disease 2019 infected patientcoronavirus disease 2019 infectioncoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 spike glycoproteincoronavirus disease 2019 spike proteincoronavirus disease 2019 viruscoronavirus disease infected patientcoronavirus disease patientcoronavirus disease positive patientcoronavirus disease-19coronavirus disease-19 patientcoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientcytokinecytokine release syndromecytokine stormdata interpretationdevelopmentaldisease severitydsRNAenzyme linked immunoassayflow cytophotometrygraduate studenthCoV19host responsehuman modelimmune activationimmune cell infiltrateimmune modulatorsimmune system responseimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimmunoresponsein vivoinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2infection with SARS-CoV-2inflammatory environmentinflammatory milieuinnate immune mechanismsinnate immune pathwaysinsightinterferon beta 2life-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2lung pathologymedical collegemedical schoolsmelanoma differentiation associated gene 5melanoma differentiation associated protein 5model of humanmortalitymortality ratemouse modelmultiomicsmultiorgan failuremultiple omicsmultiple organ system failuremurine modelnCoV2nanostringnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetpanomicspathwaypatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2post-docpost-doctoralpost-doctoral traineepreparationspreventpreventingprotocol developmentpulmonaryresearch associatesresponsescRNA sequencingscRNA-seqschool of medicinesensorserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 pathogenesissevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2single cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolespike proteins on SARS-CoV-2transduced cellstransgeneviral RNAviral infectionviral multiplicationviral replicationvirus RNAvirus genomevirus host interactionvirus infectionvirus multiplicationvirus pathogenesisvirus proteinvirus-induced diseasewet lung
Description preview
PROJECT ABSTRACT
Immune dysregulation is a hallmark of severe COVID-19 caused by infection with severe acute
respiratory syndrome coronavirus 2 (SCoV2). The pathogenesis of immune dysregulation in COVID-19 is
thought to involve a dysfunctional host innate immune response, including a discordant type I interferon
(T1IFN) response relative to viral…
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