grant
The role for ER associated degradation (ERAD) in T cell homeostasis and memory
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 17 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026APF-1ATP-Dependent Proteolysis Factor 1AcuteAntigensApoptoticAreaAutoregulationBiochemical PathwayCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancersCell BodyCell Communication and SignalingCell DeathCell SignalingCell SurvivalCell ViabilityCellsCessation of lifeChronicCommunicable DiseasesComplexCytosolDataDeathER stressEndoplasmic ReticulumEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumErgastoplasmGene TranscriptionGeneticGenetic TranscriptionGoalsHMG-20High Mobility Protein 20HomeostasisHumanImmuneImmune responseImmunesImmunityIn VitroInfectionInfectious DiseasesInfectious DisorderIntermediary MetabolismIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceKnowledgeLCM VirusesLCMVLymphocytic choriomeningitis virusMaintenanceMalignant NeoplasmsMalignant TumorMeasurementMediatingMediatorMemoryMetabolic NetworksMetabolic ProcessesMetabolic dysfunctionMetabolismMiceMice MammalsModern ManMolecularMurineMusNull MousePathway interactionsPhysiological HomeostasisProteinsPublic HealthQuality ControlRNA ExpressionReporterResearchRestRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingT cell differentiationT cell responseT-CellsT-LymphocyteT8 CellsT8 LymphocytesTestingTherapeuticTranscriptionTransgenic OrganismsUbiquitinVaccinationViral DiseasesVirus DiseasesWorkaberrant folded proteinaberrant folded proteinsabnormal folded proteinabnormal folded proteinsarmbalancebalance functionbiological signal transductiondesigndesigningendoplasmic reticulum stressepigeneticallyexperiencehost responseimmune system responseimmunogenimmunoresponseimprovedin vivoinhibitorinsightmalignancymisfolded proteinmisfolded proteinsmitochondrial metabolismnecrocytosisneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathogenpathwaypharmacologicpreservationpreventpreventingprotein homeostasisproteostasisproteotoxic proteinproteotoxinresponsesocial rolethymus derived lymphocytetransgenictumorvaccine responsevaccine responsivenessvaccine-induced responseviral infectionvirus infectionvirus-induced disease
Description preview
PROJECT SUMMARY
CD8+ T cells are critical to eradicate viral infections and tumors, as well as providing
long-lasting protection; however, not all immune responses elicit functional and durable immune
responses leading to loss of protection against intracellular pathogens and cancer. Effective T
cell immunity requires tight control to maintain…
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