grant
The Relationship of Exercise Associated Cardiac Reserve on Peak Oxygen Consumption and Frailty Measures in Individuals Undergoing Allogeneic Hematopoietic Stem Cell Transplant.
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AML - Acute Myeloid LeukemiaAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAddressAllogenicAssessment instrumentAssessment toolBiomedical EngineeringBody Weight decreasedCanadaCancer CenterCancer TreatmentCancersCardiacCardiac OutputCardiopulmonaryCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemClinicalClinical ManagementClinical OncologyClinical TrialsCollectionCommunitiesCoupledDataDevelopment PlansDiseaseDisorderDoctor of PhilosophyEarly DiagnosisElderlyEligibilityEligibility DeterminationEnvironmentEquationEquipmentEvaluationExclusionExerciseExercise ToleranceExposure toFeasibility StudiesFutureGait speedGasesGoalsHSC transplantationHealthHeart VascularHeart failureHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHematopoietic Stem Cell TransplantHematopoietic Stem Cell TransplantationIatrogenic CancerImaging ProceduresImaging TechnicsImaging TechniquesImpairmentIndividualInternationalIntravenousInvestigatorsIonizing Electromagnetic RadiationIonizing radiationK23 AwardK23 MechanismK23 ProgramLifeMR ImagingMR TomographyMRIMRIsMagnetic ResonanceMagnetic Resonance ImagingMalignant Hematologic NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorsMethodologyMethodsMorbidityMuscleMuscle TissueMyocardial depressionMyocardial dysfunctionNMR ImagingNMR TomographyNuclear Magnetic Resonance ImagingO elementO2 elementOncologistOncologyOncology CancerOutcomeOxygenOxygen ConsumptionPatientsPeripheralPh.D.PhDPhenotypePhysical PerformancePhysical activityPhysiciansPlayPrincipal InvestigatorProceduresProtocol ScreeningPublicationsQOLQOL improvementQualifyingQuality of lifeRadiation-Ionizing TotalRelapseReproducibilityResearchResearch PersonnelResearch TrainingResearchersRiskRoleScientific PublicationScientistSerious Adverse EventSevere Adverse EventStressSurvivorsSyndromeTechniquesTestingTherapeutic InterventionTherapy Related Malignant NeoplasmTherapy Related Malignant TumorTherapy-Associated CancersTherapy-Related CancerTimeTrainingTransplant RecipientsTransplantationTreatment-Associated CancerTreatment-Related CancerVirginiaWeight LossWeight ReductionZeugmatographyacute granulocytic leukemiaacute myeloid leukemiaadvanced ageadverse event riskanti-cancer therapybio-engineeredbio-engineersbioengineeringbiological engineeringblood stem cell transplantationbody weight losscancer therapycancer-directed therapycardiac MRIcardiac dysfunctioncardiac failurecardiac functioncardiac imagingcardiac magnetic resonance imagingcardiac scanningcardiovascular disordercareer developmentcirculatory systemco-morbidco-morbiditycofactorcomorbiditycurative interventioncurative therapeuticcurative therapycurative treatmentsdeath riskdesigndesigningdisabilityearly detectionelderly patiententhusiastic atmosphereenthusiastic environmentexercise capacityexercise intoleranceexercise physiologistexhaustionfrailtyfunction of the heartfunctional statusgeriatricheart dysfunctionheart functionheart imagingheart outputheart scanninghematopoietic cell transplantationhematopoietic cellular transplantationhematopoietic progenitor cell transplantationimprovedimproved outcomeimprovements in QOLimprovements in quality of lifeinnovateinnovationinnovativeinterestintervention therapyionizing outputleukemialeukemia treatmentleukemic therapymalignancymortalitymortality riskmultidisciplinarymuscularneoplasm/cancernovelolder patientpatient centeredpatient orientedprogramsquality of life improvementresponsible research conductsenior citizenserious adverse experienceserious adverse reactionside effectsocial rolesuccesssupportive atmospheresupportive environmenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttemporal measurementtemporal resolutiontheoriestime measurementtranslational investigatortranslational researchertranslational scientisttransplanttransplant patienttransplant therapytransplant treatmenttransplantation therapytransplantation treatmentwt-loss
Description preview
PROJECT SUMMARY
This K23 project will prepare the Principal Investigator, Justin M. Canada, PhD, to develop as an
independent clinical/translational researcher who is expert in a novel form of cardiopulmonary exercise stress
measurement – cardiovascular magnetic resonance imaging (MRI) – to identify factors that reduce peak
oxygen consumption…
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