grant
The promotion of parental behavior by the neurosteroid allopregnanediol
Organization COLUMBIA UNIV NEW YORK MORNINGSIDELocation NEW YORK, UNITED STATESPosted 15 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20250-11 years old4-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidActive Follow-upAdrenal CortexAllopregnanoloneAminalonAminaloneAnxietyAquadiolBehaviorBehavioralBiologyBlood PlasmaBrainBrain Nervous SystemBrain regionCaringCell Communication and SignalingCell SignalingChildChild DevelopmentChild RearingChild YouthChildren (0-21)ClinicalCommon Rat StrainsCorpus Luteum HormoneCoupledDataDeer MouseDelta4-pregnene-3,20-dioneDimenformonDiogynDiogynetsDoseDrugsElectrophysiologyElectrophysiology (science)EncephalonEndocrine Gland SecretionEpilepsyEpileptic SeizuresEpilepticsEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineExperimental GeneticsFathersFemaleGABAGABA ReceptorGenomicsHormonalHormonesHourHouse miceHumanHuman DevelopmentHydroxyprogesteroneIndividualIndividual DifferencesInfantInfant and Child DevelopmentIntracellular Communication and SignalingInvestigationKnock-outKnockoutKnowledgeLaboratoriesLifeLigandsMeasuresMedicationMiceMice MammalsModern ManMolecularMothersMotivationMuridaeMuridsMurineMusMus musculusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyOvocyclinOvocylinParentingParenting behaviorParentsPatientsPatternPeromyscusPharmaceutical PreparationsPhasePhysiologyPlasmaPlasma SerumPost-Natal DepressionPost-Partum DepressionPostnatal DepressionPostpartum DepressionPregn-4-ene-3,20-dionePregnenedioneProgesteroneProgesterone ReceptorsProgestin ReceptorsProgynonRatRats MammalsRattusReceptor ProteinResearchReticuloendothelial System, Serum, PlasmaRodentRodentiaRodents MammalsSeizure DisorderShapesSignal TransductionSignal Transduction SystemsSignalingSisterSiteSocial Support SystemSupport SystemSynapsesSynapticSystemTestingTherapeutic EstradiolTherapeutic HormoneTherapeutic ProgesteroneTherapeutic Steroid HormoneUnited StatesVariantVariationWomanWorkactive followupadrenal gland cortexantagonismantagonistbiological signal transductioncell typechild neglectchildhood neglectchildrearingdeermousedrug/agentelectrophysiologicalepilepsiaepileptogenicexperimentexperimental researchexperimental studyexperimentsfollow upfollow-upfollowed upfollowupgamma-Aminobutyric Acidgamma-Aminobutyric Acid Receptorsgene manipulationgenetic manipulationgenetically manipulategenetically perturbkidsmaleneglectneuroactive steroidsneuronalneurosteroidsnovelparentpremenstrual dysphoric disorderreceptorsteroid hormonesynapsetoolyoungsterγ-Aminobutyric Acid♀♂
Description preview
Summary
Around 15% of women suffer from postpartum depression, which negatively impacts their motivation to care for
their infants. Beyond postpartum depression, more than 600,000 children suffer from parental abuse or neglect
(largely by parents themselves) in the United States, every year. Given how important parental care is to child…
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