grant
The Phex Pathway: Mechanisms Underlying a Meniere's Disease Subtype
Organization MASSACHUSETTS EYE AND EAR INFIRMARYLocation BOSTON, UNITED STATESPosted 1 May 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025Animal ModelAnimal Models and Related StudiesAntibodiesAuditoryAutomobile DrivingAutopsyAutoregulationAwardBilateralBlood SerumBone GrowthCausalityCharacteristicsChromosome MappingChronicClinical TreatmentClinical Treatment MoabCochleaCochlear OrganCorti CellDNA mutationDataDegenerative DisorderDevelopmentDysfunctionEmbryoEmbryonicEndolymphatic HydropsEpithelial CellsEquilibrium Hair CellEtiologyExhibitsFailureFamilial hypophosphatemic bone diseaseFunctional disorderGene LocalizationGene MappingGene Mapping GeneticsGeneral RadiologyGenesGenetic ChangeGenetic defectGenetic mutationGenotypeGoalsGrantHair CellsHearing DisordersHearing LossHearing problemHereditaryHistologicHistologicallyHomeostasisHumanHypoacusesHypoacusisHypophosphatemic RicketsImpairmentInheritedInner Ear DisorderInstitutionInternal EarKnowledgeLaboratoriesLabyrinthLeadLinkLinkage MappingMeniere's DiseaseMeniere's DisorderMeniere's SyndromeMentorsMetabolic DiseasesMetabolic DisorderMiceMice MammalsModelingModern ManMolecularMonoclonal AntibodiesMorphologyMurineMusMutationMénière's diseaseOrphan DiseasePathway interactionsPatientsPb elementPeripheralPhenotypePhosphatesPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPhysiopathologyPlayProductionRadiographyRadiologyRadiology SpecialtyRare DiseasesRare DisorderResearchRicketsRoentgenographyRoleScientistSerumSignal PathwaySpinning SensationSubjective VertigoSurgeonSymptomsTemporal BoneTemporal bone structureTestingThesaurismosisTimeTotal Human and Non-Human Gene MappingTrainingTranscriptVIT DVertigoVestibularVestibular AqueductVestibular Hair CellsVestibular System ImpairmentVestibular defectVestibular dysfunctionVestibular lossVestibular problemsVitamin DVitamin D-Resistant RicketsWild Type MouseWorkX linked hypophosphatemia in ricketsX-Linked Hypophosphatemic RicketsX-linked hypophosphatemiaauditory diseaseauditory disorderauditory dysfunctionauditory problemcausationclinical diagnosisclinical diagnosticsclinical interventionclinical therapycohortdebilitating symptomdegenerative conditiondegenerative diseasedevelopmentaldiagnostic criteriadisabling symptomdisease causationdisease subgroupsdisease subtypedisorder subtypedrivingdysfunctional hearingear hair cellearly adulthoodemerging adultendolymphatic sacentire genomefamilial hypophosphatemia in ricketsfull genomefunctional lossfunctional mimicsgenetic mappinggenome mutationgenome sequencinghearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing diseasehearing dysfunctionhearing impairmentheavy metal Pbheavy metal leadhypophosphatemia in ricketsimprovedin uteroin vivoinner earinner ear diseasesinorganic phosphatelabyrinthine hydropslater in lifelater lifeloss of function mutationmAbsmedical diagnosticmetabolism disordermodel of animalmonoclonal Absmouse modelmurine modelnecropsyneuronal survivalorphan disorderpathophysiologypathwaypost-natal developmentpostmortempostnatalpostnatal developmentpreventpreventingprogressive hearing lossradiological imagingsocial rolespatial and temporalspatial temporalspatiotemporaltrial regimentrial treatmentvestibular deficitvestibular impairmentvestibular systemvestibular system dysfunctionwhole genomewildtype mouse
Description preview
Project Summary
Meniere’s disease (MD), a chronic inner ear disorder characterized by debilitating symptoms of
progressive hearing loss and episodic vertigo, arises from unclear etiology. Recent work from our institution
identified a distinct subtype of MD – designated MDhp – representing a group of patients with hypoplasia of the
endolymphatic…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click