grant
The PDIM paradox of M. tuberculosis
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AffectAnimalsAntibiotic AgentsAntibiotic DrugsAntibioticsApplications GrantsAssayAtlasesAutoradiographyBSL-3 facilityBSL3 facilityBacteriaBioassayBiological AssayCell BodyCell WallCellsCessation of lifeClinicalCommunicable DiseasesCommunitiesComplexCulture ProcedureDNA mutationDeathDevelopmentDiagnosticDisease ProgressionDrug ToleranceDrug resistanceDrugsEngineeringEnvironmentEquipmentEvolutionExposure toFrequenciesGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGrant ProposalsGrowthHeterogeneityHydrophobicityImmune systemIn VitroInfectionInfectious DiseasesInfectious DisorderIntermediary MetabolismLaboratory ProceduresLaboratory cultureLibrariesLipidsLiquid substanceM bovisM tbM tuberculosisM tuberculosis H37RvM. bovisM. tbM. tuberculosisM. tuberculosis H37RvM. tuberculosis complexM.tb complexMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicationMembraneMetabolic ProcessesMetabolismMethodsMiceMice MammalsMiscellaneous AntibioticModelingMtb complexMurineMusMutationMycobacterium bovisMycobacterium tuberculosisMycobacterium tuberculosis H37RvMycobacterium tuberculosis complexMycobacterium tuberculosis var. bovisPathogenesisPathogenicity FactorsPathologicPermeabilityPharmaceutical PreparationsPhenotypePopulationPopulation HeterogeneityPredispositionProceduresProductionPropionatesProtocolProtocols documentationRadioautographyReproducibilityResearchRoleScreening procedureSolidStructureSupplementationSusceptibilityTestingTherapeuticThin Layer ChromatographyTimeTissue GrowthUncertaintyVancomycin ResistanceVirulenceVirulence FactorsWorkannual screeninganti-microbialantimicrobialattenuationbiosafety level 3 facilitycell envelopecostcost effectivedeep sequencingdesigndesigningdevelopmentaldisease heterogeneitydiverse populationsdoubtdrug efficacydrug resistantdrug/agententire genomeexperimentexperimental researchexperimental studyexperimentsfluidfull genomegene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome mutationgenome sequencingheterogeneous populationin vivoinstrumentliquidmembrane structuremortalitymouse modelmtbmurine modelmycobacterialontogenypathogenpopulation diversitypreventpreventingresistance to Drugresistance to vancomycinresistant to Drugresistant to vancomycinroutine screeningscreeningscreening toolsscreeningsskillssmall moleculesocial roletoolvaccine efficacyvancomycin resistantwastingwhole genome
Description preview
Project Summary
Mycobacterium tuberculosis (Mtb) has been the leading cause of infectious disease mortality worldwide for the
past few decades with more than 1 million deaths annually. This pathogen has an exceptionally complex cell
wall structure, the outer components of which are important for direct interactions with the host, for giving…
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