grant
The opposing effects of matrix aging and muscle activity on extracellular vesicle promotion of muscle regeneration
Organization SPAULDING REHABILITATION HOSPITALLocation CHARLESTOWN, UNITED STATESPosted 15 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AcuteAdverse effectsAgingArchitectureBiogenesisBiologic ModelsBiological ModelsBiophysicsBody TissuesCartilageCartilaginous TissueCell AgingCell BodyCell Communication and SignalingCell IsolationCell LineageCell SegregationCell SenescenceCell SeparationCell Separation TechnologyCell SignalingCell-Extracellular MatrixCellsCellular AgingCellular SenescenceCharacteristicsCollagenCommunicationCuesDataDecline in mobilityDecrease in mobilityDecreased mobilityDefectDiminished mobilityDistalECMElastic TissueElasticityElderlyEngineeringEngineering / ArchitectureEventExerciseExperimental ModelsExtracellular MatrixFibrosisFunctional RegenerationFunctional impairmentGoalsHealthHumanImpairmentIn VitroInjuryIntracellular Communication and SignalingIntramuscularInvestigationLipidsMediatingMedicineMitochondriaMobility declineMobility impairmentModel SystemModern ManMolecularMuscleMuscle FibersMuscle TissueMyotubesNatural regenerationNetwork AnalysisNucleic AcidsOlder PopulationOrigin of LifePathogenicityPathway AnalysisPhysical activityPhysiologicPhysiologicalPlayPopulationPrintingProcessProgenitor CellsPropertyProteinsProtocolProtocols documentationPublishingRNA SeqRNA sequencingRNAseqRecovery of FunctionReduced mobilityReduction in mobilityRegenerationRegenerative responseRejuvenationReplicative SenescenceReproducibilityReserve CellRhabdomyocyteRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSkeletal muscle injurySmall RNASpecific qualifier valueSpecifiedTestingTimeTissuesVoluntary MuscleWorkadvanced ageage associatedage associated alterationsage associated changesage associated effectsage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage effectage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related effectsage specificage specific alterationsage specific changesagedaged muscleaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging effectaging induced alterationsaging induced changesaging of muscleaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with agebiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencescell sortingchanges with agecrosslinkdecline in functiondecline in functional statusdesigndesigningelectromyostimulationextracellular vesiclesfunctional declinefunctional recoveryfunctional status declinegeriatrichealingimpact of ageimprovedin vivoin vivo Modelinfluence of ageinjuriesinjury recoveryloss of functionmechanical loadmitochondrialmouse modelmurine modelmuscle agingmuscle progenitormuscle progenitor cellmuscle regenerationmuscle stem cellmuscularnanoneuromuscular Electrical Stimulationneuromuscular stimulationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyolder adultolder adulthoodolder groupsolder individualsolder personosteogenicphysical impairmentprogenitor cell fateprogenitor cell functionprogenitor fateprogenitor functionrecovery after injuryrecovery following injuryrecovery post injuryregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregeneration functionregeneration potentialregeneration responseregenerative functionregenerative functionalityregenerative potentialrepairrepairedreplicative agingresilienceresilientresponsescaffoldscaffoldingsenior citizensocial rolestem and progenitor cell fatestem and progenitor cell functionstem and progenitor functionstem cell fatestem cell functionstem cellstherapeutic agent developmenttherapeutic developmenttissue regenerationtissue regrowthtissue renewaltissue specific regenerationtranscriptome sequencingtranscriptomic sequencinguptakevesicle releasevesicular releaseviscoelasticity
Description preview
ABSTRACT
Young skeletal muscle displays remarkable resilience following an acute injury event, evidenced by a
robust regenerative response and functional recovery. In contrast, even a relatively minor injury to aged
muscle can result in significant functional impairments owing to compromised regeneration. Numerous studies
have identified muscle…
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