grant
The nuclear Ferredoxin reductase and its role in tumor suppression
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AcetylationActive OxygenAcuteAntioncogene Protein p53BindingBiochemicalBiogenesisBiological FunctionBiological ProcessBiologyBreastBreast Cancer CellCancersCell BodyCell Communication and SignalingCell DeathCell NucleusCell SignalingCell SurvivalCell ViabilityCellsCellular ExpansionCellular GrowthCellular Tumor Antigen P53ClassificationCoenzyme IIColon or RectumColorectalColorectal CarcinomasDNA BindingDNA Binding DomainDNA Binding InteractionDNA DamageDNA InjuryDNA Repair EnzymesDNA ReplicationDNA SynthesisDNA biosynthesisDNA boundDNA mutationDNA-Binding Protein MotifsData BasesDatabasesDehydrogenasesElectronsElementsEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExonsFe elementFerredoxinFlavoproteinsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGerminoblastic SarcomaGerminoblastomaHealthHeme IronHumanInduction of ApoptosisIntracellular Communication and SignalingIronIsoformsKinasesKnowledgeLarge Bowel CarcinomaLarge Intestine CarcinomaLungLung Respiratory SystemLymphomaMalignant LymphomaMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMediatingMiceMice MammalsMitochondriaMitochondrial ProteinsModern ManMolecular InteractionMolecular Tumor SuppressionMurineMusMutateMutationNAD phosphateNAD(H) phosphateNADH phosphateNADPNADPHNLS PeptideNegative Beta ParticleNegatronsNicotinamide-Adenine Dinucleotide PhosphateNormal TissueNormal tissue morphologyNuclearNuclear Localization SignalNuclear Localization Signal PeptideNucleusOncoprotein p53Origin of LifeOxidation-ReductionOxidative StressOxidoreductaseOxidoreductase GeneOxygen RadicalsP53PDX modelPathway interactionsPatient derived xenograftPhosphoprotein P53Phosphoprotein pp53PhosphorylationPhosphotransferase GenePhosphotransferasesPilot ProjectsPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPro-OxidantsPrognosisProtein IsoformsProtein ModificationProtein PhosphorylationProtein TP53ProteinsProteomicsPulmonary CancerPulmonary malignant NeoplasmReactive Oxygen SpeciesRedoxReductasesReticulolymphosarcomaRing FingerRing Finger DomainRing Finger MotifRing-Type Zinc Finger DomainRoleS elementSignal TransductionSignal Transduction SystemsSignalingSteroid CompoundSteroidsStressStructureSulfurSystematicsTCGATP53TP53 geneTRP53TestingThe Cancer Genome AtlasTimeTranscriptTransphosphorylasesTriphosphopyridine NucleotideTumor Protein p53Tumor Protein p53 GeneTumor SuppressionTumor TissueZincZinc Finger DomainZinc Finger MotifsZinc FingersZn elementbiological signal transductionbreast tumor cellcell growthcolorectumdata basedesensitizationenzyme activityepigeneticallyerastingenome mutationheme alife spanlifespanlung cancermalignancymitochondrialnecrocytosisneoplasm/cancernoveloxidation reduction reactionp53 Antigenp53 Genesp53 Tumor Suppressorpathwaypatient derived xenograft modelpilot studypromoterpromotorprotein p53pyruvate dehydrogenaserepairrepairedresponsesensorsocial roletumor
Description preview
Project Summary/Abstract
We and others showed that ferredoxin reductase (FDXR), a mitochondrial flavoprotein, is induced by
DNA damage in a p53-dependent manner and regulates apoptosis induced by reactive oxygen species.
As the only human ferredoxin reductase, FDXR receives two electrons from NADPH and transfers them
one at a time to its cognate…
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