grant
The novel role of perivascular fibroblasts in secondary injury after cervical SCI
Organization FLORIDA INTERNATIONAL UNIVERSITYLocation MIAMI, UNITED STATESPosted 13 May 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026Anatomic SitesAnatomic structuresAnatomyAntibody TherapyAntiproteasesBleedingBloodBlood Reticuloendothelial SystemBlood VesselsBody TissuesBruiseCell BodyCell Communication and SignalingCell SignalingCell-Extracellular MatrixCellsCervicalCervical InjuryCervical spinal cord injuryCicatrixClinicalContusionsDataDevelopmentDistantDropsyDysfunctionECMEdemaEmotionalEndopeptidase InhibitorsExtracellular MatrixExtravasationFaceFibroblastsFunctional disorderFunctional impairmentGeneticGoalsHemorrhageHydropsIFN-GammaIFN-gIFN-γIFNGIFNγImmuneImmune InterferonImmune infiltratesImmunesInfiltrationInfusion PumpsInfusorsInjuryInnovative TherapyInterferon GammaInterferon Type IIIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceLeakageLesionMechanicsMediatingMedulla SpinalisNull MouseOutcomePalsyParalysedPathologyPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPeptidase InhibitorsPeptide Hydrolase InhibitorsPeptide Peptidohydrolase InhibitorsPerfusion PumpsPeripheralPermeabilityPhysiopathologyPlayPlegiaProductivityProliferatingProtease AntagonistsProtease InhibitorProteinase InhibitorsQOLQOL improvementQuality of lifeReceptor ProteinRecovery of FunctionRoleSCI PatientsScarsSecondary toSignal TransductionSignal Transduction SystemsSignalingSiteSpillageSpinal CordSpinal Cord TraumaSpinal TraumaSpinal cord injuredSpinal cord injurySpinal cord injury patientsTestingTherapeuticTissuesTraumatic MyelopathyTreatment PeriodUpregulationantibody based therapiesantibody treatmentantibody-based therapeuticsantibody-based treatmentaxon regenerationaxonal regenerationbiological signal transductionblood damageblood lossclinical translationclinically translatabledevelopmentaleffective therapyeffective treatmentfacesfacialfunctional lossfunctional outcomesfunctional recoveryimmune cell infiltrateimproved outcomeimprovements in QOLimprovements in quality of lifein vivoinjuriesinsightlFN-Gammamechanicmechanicalmigrationneural inflammationneuroinflammationneuroinflammatoryneuroprotectionneuroprotectiveneutralizing antibodynew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetoverexpressoverexpressionparalysisparalyticpathophysiologypathwaypatient oriented outcomespharmacologicquality of life improvementreceptorsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettherapy optimizationtreatment daystreatment durationtreatment optimizationvascular
Description preview
Spinal cord injury (SCI) is a devastating condition that causes profound physical and emotional suffering, yet
effective treatments remain unavailable. Developing new therapies to mitigate SCI outcomes represents a
critical unmet clinical need. Disruption of the blood-spinal cord barrier (BSCB) leads to peripheral immune cell
infiltration,…
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