grant
The novel role of MIF-CD74 inflammatory pathway in immune regulation
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Dec 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY2025AcuteAffectAllograftingAntigensAssayAutocrine SystemsAutoregulationBALB C MouseBALB/cBasal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCardiac TransplantationCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChIP SequencingChIP-seqChIPseqChronicClinical Treatment MoabCo-ImmunoprecipitationsComplexDataDoseEragrostisExhibitsFDA approvedFOXP3FOXP3 geneFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryForkhead Box P3Gene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGeneticGenetic TranscriptionGrafting ProcedureHeart GraftingHeart TransplantationHomeostasisHumanIFNIRF-1IRF1IRF1 geneImmuneImmunesImmunomodulationImpairmentIn VitroInbred BALB C MiceInfiltrationInflammationInflammatoryInnate ImmunityInterferon Regulatory Factor 1InterferonsIntracellular Communication and SignalingJM2LYT3Lineage TracingLuciferase ImmunologicLuciferasesMacrophageMacrophage Migration Inhibition FactorsMacrophage Migration Inhibitory FactorMediatingMiceMice MammalsMigration Inhibition FactorMigration Inhibitory FactorModelingModern ManMolecularMolecular InteractionMonoclonal AntibodiesMurineMusMyD32 proteinMyeloid CellsMφNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityOrgan TransplantationOrgan TransplantsOutcomePathway interactionsPhenotypePhysiological HomeostasisPlayProcessProliferatingRNA ExpressionReceptor ProteinRegimenRegulatory T-LymphocyteRoleSCURFINSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSolidSpecificitySubcellular ProcessSurfaceT cell receptor repertoire sequencingT cell receptor sequencingT memory cellT-CellsT-LymphocyteT8 CellsT8 LymphocytesTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTamoxifenTechniquesTechnologyTeffTeff cellTestingTherapeuticTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenic MiceTransplant RecipientsTransplantationTransplantation ToleranceTreatment EfficacyTregWorkadaptive immunityallograft rejectionalloimmunityarylpyruvate keto-enol tautomeraseautocrinebiological signal transductioncardiac allograftcardiac graftcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingclinical relevanceclinically relevantconditional knock-outconditional knockoutcytokinecytotoxicdraining lymph nodeeffector T cellexhaustionflow cytophotometryheart allograftheart transplantimmune modulationimmune regulationimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryin vivoinsightinterferon-stimulated gene factor 1intervention efficacyisoimmunitymAbsmemory T lymphocytemonoclonal Absnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyorgan allograftorgan graftorgan xenograftp-hydroxyphenylpyruvate tautomerasepathwayphenylpyruvate tautomeraseprogramspromoterpromotorreceptorregional lymph noderegulatory T-cellsresponsesocial roletherapeutic efficacytherapeutic targettherapy efficacythymus derived lymphocytetranscription factortranscriptomicstranslational opportunitiestranslational potentialtransplanttransplant modeltransplant patient
Description preview
Inflammation negatively affects Tregs stability and suppressive function, impairs the
induction of solid organ transplant tolerance and enhances acute and chronic rejection, leading
to worse recipients’ long-term outcomes. Insights into key inflammatory pathways that suppress
Tregs during allo-immune activation can revolutionize our therapeutic…
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