grant
The novel role of HLA-E restricted CD8 regulatory T cells in kidney allograft rejection
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 12 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025Ab responseAccelerationAgonistAllelesAllelomorphsAllogenicAllograftingAntibody FormationAntibody ProductionAntibody ResponseAntibody TherapyAntigensAutoimmune StatusAutoimmunityB blood cellsB cellB cell differentiationB cellsB lymphocyte differentiationB-CellsB-LymphocytesB-cellBindingBiologyBlocking AntibodiesC 4dC4dCD122CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD44CD44 geneCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCRISPRCRISPR/Cas systemCell Communication and SignalingCell Growth in NumberCell MaturationCell MultiplicationCell ProliferationCell SignalingCellular ProliferationChronicClinicalClustered Regularly Interspaced Short Palindromic RepeatsComplement ActivationComplexCytotoxic cellDataDepositDepositionDevelopmentE proteinGenerationsGenesGeneticGenetic PolymorphismGenetics-MutagenesisGerminal CenterGraft RejectionGraft SurvivalH-2Q1Helper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHumanIL2RBIL2RB geneImmune responseInducer CellsInducer T-LymphocytesInfectionInjuryIntracellular Communication and SignalingK lymphocyteKI miceKLRA1KLRA1 geneKO miceKidneyKidney GraftingKidney TransplantationKidney TransplantsKidney Urinary SystemKnock-in MouseKnock-out MiceKnockout MiceLCM VirusesLCMVLY49LY49LLYT3LaboratoriesLymphocytic choriomeningitis virusMDU3MHC ReceptorMajor Histocompatibility Complex ReceptorMediatingMiceMice MammalsModelingModern ManMolecular InteractionMurineMusMutagenesisMutagenesis Molecular BiologyMutant Strains MiceNK CellsNatural Killer CellsNull MouseOutcomeP70-75PatientsPeptidesPgp1Point MutationProductionProliferatingPublishingQa-1Qa-1 AntigenQa1Qed-1Receptor ProteinRegimenRegulatory T-LymphocyteRenal GraftingRenal TransplantationRenal TransplantsReportingResearchRoleSignal TransductionSignal Transduction SystemsSignalingSpecificityStressStructure of germinal center of lymph nodeStudy modelsSurfaceSystemT-Cell ActivationT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell Receptor InteractionT-CellsT-LymphocyteT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTCR ActivationTCR InteractionTestingTimeTissue GraftsTransgenic MiceTransplant RejectionTransplantation RejectionTregactivate T cellsallograft rejectionalloimmunityantibody based therapiesantibody biosynthesisantibody rejectionantibody treatmentantibody-based therapeuticsantibody-based treatmentantibody-mediated rejectionantigen based testantigen testantigen-specific T cellsbiological signal transductionclinical relevanceclinical significanceclinical translationclinically relevantclinically significantclinically translatablecomplement 4dcomplement C4dcomplement pathway regulationdefined contributiondevelopmentaldonor antibodiesdonor-specific antibodyhost responseimmune system responseimmunogenimmunoglobulin biosynthesisimmunoresponseimprovedin vivoinjuriesisoimmunitykidney allograftkidney txknockin micemouse modelmouse mutantmurine modelnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetpathogenpeptide immunizationpeptide vaccinationpolymorphismreceptorregulatory T-cellsrenalrenal allograftresponsesocial rolethymus derived lymphocytetissue graftingtooltranslatable strategytranslational opportunitiestranslational potentialtransplant model
Description preview
Antibody-mediated rejection (AMR) in kidney transplantation remains a major cause of kidney graft loss
and a critical hurdle to improve long term allograft survival, with no approved therapy. Antibody responses are
tightly controlled through T follicular helper (Tfh) cells. Understanding the role of Tfh in kidney transplant and
developing…
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