grant
The Multi-omics Vaccine Evaluation (MOVE) Consortium
Organization SCRIPPS RESEARCH INSTITUTE, THELocation LA JOLLA, UNITED STATESPosted 1 Jun 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusAccelerationAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody ResponseAntibody SpecificityAntigenic DeterminantsAntigensApicalB blood cellsB cellB cell repertoireB cellsB-CellsB-LymphocytesB-cellBinding DeterminantsBlood SerumBody TissuesCell BodyCellsCollaborationsComputational toolkitDevelopmentEpitopesEvaluationFrequenciesGeneticGlycansGoalsHIVHIV AntibodiesHIV vaccineHIV-Associated AntibodiesHIV/AIDS VaccinesHTLV-III AntibodiesHTLV-III-LAV AntibodiesHistoryHu-mABsHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III AntibodiesImmune responseImmunityImmunizationIndividualInformaticsInvestigatorsLAV AntibodiesLAV-HTLV-IIILymphadenopathy-Associated AntibodiesLymphadenopathy-Associated VirusMissionModern ManPatternPolysaccharidesProductivityProliferatingProteomicsProtocolProtocols documentationRecording of previous eventsResearch PersonnelResearchersResolutionSeriesSerumSiteSpecificitySpeedSpinal ColumnSpineTechniquesTechnologyTestingTissuesVaccinesVertebral columnViralVirus-HIVbackbonecomputational toolboxcomputational toolscomputational toolsetcomputerized toolsdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalevaluate vaccineshistorieshost responsehumAbshuman immunodeficiency virus vaccinehuman mAbshuman monoclonal antibodieshuman monoclonalshumanized micehumanized mouseimmune system responseimmunogenimmunogenicityimmunoresponseimprovedinnovateinnovationinnovativemodel of animalmultidisciplinarymultiomicsmultiple omicsneutralizing antibodynovelpandemicpandemic diseasepanomicsparallelizationresolutionstoolvaccine developmentvaccine evaluationvaccine screeningvaccine testing
Description preview
PROJECT SUMMARY
An HIV vaccine represents our best opportunity for eliciting durable, protective immunity and ending the
decades-long AIDS pandemic. To be successful, an antibody-based HIV vaccine must reliably induce broadly
neutralizing antibodies (bnAbs), most likely via a series of immunogens or mixtures of immunogens delivered
sequentially.…
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