grant
The Molecular Regulatory Mechanism of Tooth Root Development
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 19 Jul 2012Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025Alveolodental LigamentAlveolodental MembraneAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAtlasesBasal Transcription FactorBasal transcription factor genesBite ForceCell BodyCell Communication and SignalingCell Cycle ControlCell Cycle ProgressionCell Cycle RegulationCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCephalicChewingCorona DentisCranialCranial Nerve VCraniofacial AbnormalitiesCrownsDNA Synthesis FactorDataDefectDentalDentitionDevelopmentEndothelial Cell Growth FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumEsthesiaFGFFaceFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Regulatory FactorFifth Cranial NerveGLI Family GeneGLI Family ProteinGLI ProteinGLI geneGLI1GLI1 GeneGLI1 ProteinGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGlioma Associated Oncogene Homolog 1 ProteinGlioma Associated Oncogene Homolog ProteinGlioma-Associated Oncogene HomologGlioma-associated oncogeneInferior Maxillary BoneIntracellular Communication and SignalingJawKnowledgeMandibleMasticationMasticatory ForceMaxillaMechanicsMediatingMediatorMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMesenchymasMesenchymeModelingMolecularNatural regenerationNerveNervus TrigeminusNeural CrestNeural Crest CellOcclusal ForceOrganogenesisPathway interactionsPatternPeriodontal LigamentPeriodontal MembranePiezo 1Piezo 1 ion channelPiezo 2Piezo 2 ion channelPiezo1Piezo2PlayPositionPositioning AttributeProcessProgenitor CellsProteinsRNA ExpressionRadix DentisRegenerationRegulationResearch DesignRoleSensationShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpecificitySpeechStudy TypeSubcellular ProcessTestingToothTooth CrownsTooth RootTooth root structureTooth structureTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransmissionTrigeminal NerveTrigeminal nerve structureVascular blood supplyWNT Signaling PathwayWNT signalingWorkbalancebalance functionbiological signal transductionbite strengthblood supplybonechewedchewscraniofacial anomaliescraniofacial defectscraniofacial malformationdevelopmentalepigeneticallyfacesfacialglioma associated oncogene 1glioma associated oncogene family zinc finger 1inhibitorinnervationmandibularmaxillarymechanicmechanicalmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmodel of animalnerve supplyneuro-vascularneurovascularpathwayprogenitorprogenitor cell fateprogenitor fateregeneratescRNA sequencingscRNA-seqsensorsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial and temporalspatial temporalspatiotemporalstem and progenitor cell fatestem cell fatestem cellsstudy designteethtranscription factortransmission processvascular supply
Description preview
PROJECT SUMMARY/ABSTRACT
Our dentition plays important daily roles in speech, mastication, and determination of facial shape and expression.
The tooth root is essential for the proper function of the dentition because it anchors the tooth within the maxilla
or mandible. In addition, the root helps transmit and balance occlusal forces through…
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