grant
The Molecular Profile of Prostate Tumors in African-American Men
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAffectAfricanAfrican AmericanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfrican ancestryAfrican descentAfro AmericanAfroamericanAmerican maleAmerican manAmerican menAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesAreaBacteriophagesBlood SampleBlood specimenCancer BurdenCaribbean IslandsCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCell Communication and SignalingCell SignalingChromosomesCohort StudiesCollaborationsCommunitiesConcurrent StudiesDataDeath RateDecrease health disparitiesDetectionDevelopmentDiseaseDisorderDrugsEnvironmentEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationEuropeanFutureGWA studyGWASGeneticGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGenomicsGerm LinesGhanaGoalsGold CoastHealth disparity mitigationHealth disparity reductionHistoryHost FactorHost Factor ProteinHumanIFNImmuneImmune RegulatorsImmune responseImmunesImmunobiologyImmunomodulatorsImmunooncologyImmunophysiologyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIncidenceIndigenousInfectionInflammationInherited PredispositionInherited SusceptibilityIntegration Host FactorsInterferonsInterventionIntracellular Communication and SignalingKnowledgeLinkLived experienceLived experiencesLower health disparitiesMalignant neoplasm of prostateMalignant prostatic tumorMapsMarylandMedicationMethodsMissionMitigate health disparitiesModern ManMolecular FingerprintingMolecular ProfilingNational Cancer BurdenNeighborhoodsOutcomePathologyPathway interactionsPatientsPeptide LibraryPhagesPharmaceutical PreparationsPollutionPopulationPopulation GroupProspective cohortProstate CAProstate CancerProstate NeoplasmsProstate TumorProstate malignancyProstatic NeoplasiaProstatic NeoplasmsRacial GroupRecording of previous eventsReduce health disparitiesResearchResearch ResourcesResourcesRiskRisk FactorsSeroprevalencesSignal TransductionSignal Transduction SystemsSignalingSocial EnvironmentStressSurvey InstrumentSurveysTechnologyTherapeuticTobagoTumor BiologyU.S. MalesUS MenUS maleViralViral DiseasesVirusVirus DiseasesWest AfricanWest Indiesbacterial virusbiological signal transductionblack maleblack manblack mencancer disparitycancer health disparitycancer-related health disparitycase-controlled studiesclinical diagnosiscohortdata integrationdeprivationdevelopmentaldisease disparitydisparity in cancerdrug/agentenvironmental agentenvironmental riskepigeneticallyethnic subgroupethnicity groupgene signaturesgenetic associationgenetic etiologygenetic mechanism of diseasegenetic signaturegenetic vulnerabilitygenetically predisposedgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studyhistorieshost responsehuman viromeimmune modulatorsimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune-oncologyimmuno oncologyimmunology oncologyimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedindexinginflammation markerinflammatory markerliver cancer patientmales in Americamales in the U.S.males in the USmales in the USAmales in the United Statesmalleable riskmenmen in Americamen in the U.S.men in the USmen in the USAmen in the United Statesmimicrymodifiable riskmolecular profilemolecular signaturemortalitymortality ratemortality rationeighborhood associationnew technologynovelnovel technologiesoncoimmunologypathogenpathwaypreventpreventingprogramsprostate cancer progressionprostate cancer riskracial populationracial subgrouprecruitsocial climatesocial contextsocioenvironmentsocioenvironmentaltraittumorviral infectionviral microbiomeviromevirus infectionvirus-induced diseasewhole genome association analysiswhole genome association study
Description preview
Currently, genomic risk, including genetic ancestry-inferred risk, is considered a nonmodifiable risk factor. Previous studies have shown that West African genetic ancestry is linked to increased prostate cancer risk among Black men, whose risk is higher than that of any other U.S. population group. However, it is unclear whether additional…
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