grant
The molecular mechanism of Siglec-E in bacterial clearance
Organization UNIVERSITY OF TENNESSEE HEALTH SCI CTRLocation MEMPHIS, UNITED STATESPosted 13 Jun 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AbbreviationsActive OxygenAnimal ModelAnimal Models and Related StudiesAntibiotic AgentsAntibiotic DrugsAntibioticsBacteriaBacterial InfectionsBindingBlood NeutrophilBlood Polymorphonuclear NeutrophilCLP modelCLP mouse modelCOVID-19CV-19Cause of DeathCecal ligation perforationCell Surface ReceptorsCessation of lifeClinicalCoronavirus Infectious Disease 2019DeathDeath RateDevelopmentE coliE. coliElderberryEscherichia coliExhibitsFamilyFluorescenceGram-Negative BacteriaGram-Positive BacteriaHospital AdmissionHospitalizationHumanIP injectionITIMImmuneImmune GlobulinsImmune PrecipitationImmune responseImmune systemImmunesImmunoglobulinsImmunoprecipitationImmunoreceptor Tyrosine-Based Inhibitory MotifIncidenceInfectionInnate Immune ResponseIntraperitoneal InjectionsKO miceKnock-outKnock-out MiceKnockoutKnockout MiceL monocytogenesL. monocytogenesLectinLectin ReceptorsLinkLipopolysaccharidesListeria monocytogenesMaackia amurensisMarrow NeutrophilMediatingMiceMice MammalsMiscellaneous AntibioticModern ManMolecularMolecular InteractionMurineMusN-Acetylneuraminic AcidsNeutrophilic GranulocyteNeutrophilic LeukocyteNull MouseOrthologOrthologous GeneOxygen RadicalsPatientsPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPositionPositioning AttributePredispositionPro-OxidantsProductionPublishingReactive InhibitionReactive Oxygen SpeciesRegulationReportingRoleS aureusS. aureusSambucusSambucus nigraSepsisSeptic ShockSialic AcidsSiteStaph aureusStaphylococcus aureusSusceptibilitySystemic Inflammatory Response SyndromeTLR proteinTestingToll-Like Receptor Family GeneToll-like receptorsTyrosineUnited StatesWild Type Mouseanti-microbialantimicrobialantisepsis treatmentbacteria infectionbacterial diseasebacterial sepsiscecal ligation and perforationcecal ligation and puncturececal ligation puncturececum ligation and puncturececum ligation punctureclinical relevanceclinically relevantcoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19designdesigningdevelopmentaleffective therapyeffective treatmentextracellularhost responseimmune system responseimmunoresponselipo-teichoic acidlipoteichoic acidmembermigrationmodel of animalmortalitymortality ratemortality ratiomouse modelmurine modelneutrophilnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpathogenpreventpreventingresponsesepsis caresepsis interventionssepsis managementsepsis therapeuticssepsis therapysepsis treatmentseptic therapyseptic treatmentsevere sepsisseverely septicsialic acid binding Ig-like lectinsialylationsiglecsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettreat sepsiswildtype mouse
Description preview
Sepsis is a systemic inflammatory response syndrome initiated by infection. Most cases of septic shock are
caused by Gram-negative bacteria, including Escherichia coli (E. coli), which remains one of the most common
pathogens leading to sepsis. Understanding the mechanisms by which the mammalian immune system
differentially responds to infection…
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