grant
The Molecular Mechanism of a Male Killing Gene
Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2025Aberrant ChromosomeAmino AcidsAnimalsArachnidaArachnidsArthropodaArthropodsBacteriaBacteriophagesBasal Transcription FactorBasal transcription factor genesBindingBinding ProteinsBiological SymbiosisBiologyBionomicsBrothersCandidate Disease GeneCandidate GeneCell BodyCellsCellular biologyCessation of lifeChIP SequencingChIP-seqChIPseqChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome abnormalityComplexCytogenetic AberrationsCytogenetic AbnormalitiesCytologyDNADNA BindingDNA Binding DomainDNA Binding InteractionDNA DamageDNA InjuryDNA boundDNA-Binding Protein MotifsDataDeathDefectDeoxyribonucleic AcidDependenceDevelopmentDisease VectorsDosage CompensationDosage Compensation (Genetics)DrosophilaDrosophila genusDrosophila melanogasterE coliE. coliEcologyEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEmbryonic InductionEscherichia coliEvolutionExtinctionFemaleFliesGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ModelsGenetic TranscriptionGenetic studyGonosomesHTH DNA Binding DomainHTH MotifsHeat ShockHeat-Shock ReactionHeat-Shock ResponseHelix-Turn-Helix MotifsHereditaryHumanImmunityInheritedInsectaInsectsInsects InvertebratesKnock-outKnockoutLigand Binding ProteinLigand Binding Protein GeneMediatingModern ManModificationMolecularMolecular InteractionMothersNematodaNematodesParasitesPartner in relationshipPest ControlPhagesPhenotypePopulationPopulation GeneticsPopulation SizesProcessProphagesProtein BindingProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqReproductionReproductive BiologyResearchResearch ResourcesResourcesRiskSecretory GranulesSecretory VesiclesSex ChromosomesSex RatioSexual ReproductionSiblingsSiteSonSpecific qualifier valueSpecifiedSpeedSystemT4SSTestingTimeTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenesTransgenic OrganismsTransmissionType IV Secretion SystemType IV Secretion System PathwayVesicleViralWolbachiaaminoacidanalyze gene expressionarboviral diseasearbovirus diseasearthropod-borne diseasearthropodborne diseasebacterial virusbasebasesbound proteincandidate validationcell biologychromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchromosomal defectchromosome defectcompare to controlcomparison controlcostdensitydevelopmentalexperiencefemale infectionsfitnessflyfocus on malefocused on menfruit flygene expression analysisgene expression assayglobal gene expressionglobal transcription profilehelix loop helixhelix turn helixinfected femalesinfected womeninfections among womeninfections in femalesinfections in womeninterestknock-downknockdownmalemale focusedmale specificmale targetedmatemicroorganismparasitismparticleprogramsreproductiveresponseroundwormsexsterile insect techniquesymbionttargeted to mentooltranscription factortranscriptional profilingtranscriptometranscriptome sequencingtranscriptomic sequencingtransgenetransgenictransmission processtype 4 secretion systemvector controlwomen experiencing infectionswomen infectionswomen with infections♀♂
Description preview
Project Summary
Sexual reproduction is a battleground for inherited bacteria and their hosts, yet how maternally-inherited bacteria
modify the reproductive biology of their host species to favor the fitness of infected females is largely unresolved.
Wolbachia are the archetypes of this adaptive strategy and exist globally in nearly half of all…
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