grant
The Microvascular Aging Effects - Women's Evaluation of Systemic aging Tenacity in Heart, Brain and Frailty (MAE-WEST HBF) ("You are never too old to become younger!")
Organization CEDARS-SINAI MEDICAL CENTERLocation LOS ANGELES, UNITED STATESPosted 15 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AD related dementiaADRDAddressAffectAgingAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAmentiaArchitectureBiological MarkersBiopsyBleedingBlood - brain barrier anatomyBlood VesselsBlood-Brain BarrierBody TissuesBrainBrain InflammationBrain Nervous SystemBrain Vascular DisordersCOBRECardiologyCardiovascular DiseasesCenter of Biomedical Research ExcellenceCenters of Research ExcellenceCerebral small vessel diseaseCerebrovascular DiseaseCerebrovascular DisordersCerebrovascular systemChronicClinicalClinical SciencesCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCoronaryDataDementiaDepositDepositionDevelopmentDiagnosisDiastolic heart failureDifferences between sexesDiffers between sexesDiseaseDisorderDisturbance in cognitionDrugsDysfunctionEicosanoidsEncephalitisEncephalonEndotheliumEngineering / ArchitectureEvaluationFe elementFemaleFemale HealthFibrosisFunctional disorderFutureGait speedGeriatricsGoalsHF with preserved ejection fractionHFpEFHealthHeartHeart Muscle tissueHemato-Encephalic BarrierHemorrhageHumanImpaired cognitionIndividualInflammationInflammatoryInfrastructureInjuryInterventionIntracranial Vascular DiseasesIntracranial Vascular DisordersInvestigationInvestigatorsIronIschemiaKinesiologyKnowledgeLV remodelingLeft Ventricular RemodelingLife CycleLife Cycle StagesLinkMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMediatingMediatorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMicrovascular DysfunctionMicrovascular PermeabilityModern ManMovement scienceMuscleMuscle TissueMyocardialMyocardial tissueNHLBINIH RFANMR ImagingNMR TomographyNational Heart, Lung, and Blood InstituteNeurologyNuclear Magnetic Resonance ImagingObstructionOrganOutcomeP50 MechanismP50 ProgramParticipantPathologistPathway interactionsPermeabilityPersonsPharmaceutical PreparationsPhenotypePhysical FunctionPhysiopathologyPre-Clinical ModelPreclinical ModelsPreventionPreventiveProcessPropertyRequest for ApplicationsResearchResearch PersonnelResearch ResourcesResearchersResourcesRiskRoleScientistSeveritiesSex DifferencesSexual differencesSiteSkeletal MuscleSpecialized CenterStructureSymptomsTestingTherapeuticTissuesVascular PermeabilitiesVoluntary MuscleWomanWomen's HealthWorkZeugmatographyage associatedage associated diseaseage associated disorderage associated effectsage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage effectage linkedage relatedage related effectsage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentaging effectbio-markersbiologic markerbiomarkerblood lossblood vessels in the brainbloodbrain barrierbrain Febrain blood vesselsbrain ironbrain vascular diseasebrain vascular dysfunctionbrain vasculatureburden of diseaseburden of illnesscardiovascular disordercerebral Fecerebral blood vesselcerebral ironcerebral small vessel disordercerebral vascular diseasecerebral vascular dysfunctioncerebral vasculaturecerebrovascular dysfunctioncerebrovascular vesselscerebrovasculaturecognitive dysfunctioncognitive losscohortcomputer based predictiondevelopmentaldisease burdendrug/agentexperiencefrailtygeriatric medicineheart failure with preserved ejection fractionheart failure with preserved systolic functionimaging scientistimpact of ageinfluence of ageinjuriesinjury to the vasculatureinjury to tissueinnovateinnovationinnovativeinsightinterestintracranial vascular dysfunctioniron in the brainleft ventricle remodelinglife courselife spanlifespanmalemenmicrovascular agingmicrovascular complicationsmicrovascular diseasemuscularnovelpathophysiologypathwaypredictive modelingpreserved ejection fraction heart failureprogramsprospectiveresponsesarcopeniasarcopenicsex based differencessex-dependent differencessex-related differencessex-specific differencessmall vessel diseasesocial roletherapeutic lifestyle changetissue injurytranslational investigatortranslational researchertranslational scientistvascularvascular injury♀♂
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PROJECT SUMMARY/ ABSTRACT- OVERALL
The Microvascular Aging Effects – Women's Evaluation of Systemic aging Tenacity in Heart, Brain and Frailty
(MAE-WEST HBF) (“You are never too old to become younger!”) Specialized Center of Research Excellence
(SCORE) on Sex Differences, in response to NIH RFA-OD-22-014, PI C. Noel Bairey Merz will extend our…
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