grant
The metabolic clock as a regulator of cell fate decision
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AddressAutoimmune DiseasesAutoimmune StatusAutoimmunityAutoregulationB blood cellsB cellB cell receptorB cellsB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellBiochemicalBone MarrowBone Marrow Reticuloendothelial SystemCalciumCancersCell BodyCell Communication and SignalingCell CycleCell DeathCell Division CycleCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCell SurvivalCell ViabilityCellsCellular AssayCellular ProliferationCessation of lifeChimeraChimera organismComplexCytoplasmDeathDegenerative DisorderDiseaseDisorderDysfunctionEnsureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumFunctional disorderGoalsHomeostasisHumanHuman FigureHuman bodyIntermediary MetabolismIntracellular Communication and SignalingLifeMalignant NeoplasmsMalignant TumorMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMitochondriaModelingModern ManMolecularMolecular TargetNeoplasmsOrganOutcomePathway interactionsPhysiological HomeostasisPhysiopathologyPlayProcessProductionProliferatingResearchRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeStimulusT-CellsT-LymphocyteTLR proteinToll-Like Receptor Family GeneToll-like receptorsTransgenic MiceWorkantigen bindingantigen boundautoimmune conditionautoimmune disorderautoimmunity diseasebalancebalance functionbiological signal transductioncell assaycell typechimerasdegenerative conditiondegenerative diseaseepigeneticallyin vivo Modelmalignancymitochondrialmitochondrial dysfunctionmouse modelmurine modelnecrocytosisneoplasianeoplasm/cancerneoplastic growthnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpathogenpathophysiologypathwaypreventpreventingsocial rolespatial and temporalspatial temporalspatiotemporalstemthymus derived lymphocyte
Description preview
Project Summary:
Our organs respond dynamically to changes in the body’s demands by adapting both their size and activity
levels. In these processes, mechanisms governing cell fate decisions, which influence the equilibrium between
cell death and cell proliferation, assume crucial roles. Although decades of research have revealed the
involvement…
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