grant
The interplay of maternal antibody and newborn vaccine responses
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 17 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20260-4 weeks old6 year old6 years of age7S Gamma GlobulinAddressAdult femalesAdult womenAge MonthsAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody ResponseAntigensAreaAssayAxillary Lymph NodeAxillary NodeAxillary lymph node groupB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBioassayBiological AssayBirthCells Placenta-TissueContracting OpportunitiesContractsDataDevelopmentDiseaseDisorderDoseFemales in adulthoodFerritinFetusFlu vaccinationFluzoneGestationGoalsGrippeHumanIgGImmuneImmune responseImmune systemImmunesImmunoglobulin GIndividualInfantInfectionInfluenzaInfluenza AInfluenza A virusInfluenza VaccinesInfluenza VirusInfluenza Viruses Type AInfluenza immunizationInfluenza vaccinationInfluenzavirus AMaternal antibodyMediatingModelingModern ManMothersNHP modelsNewborn InfantNewbornsNormal PlacentomaOrthomyxovirus Type AParturitionPlacentaPlacenta Embryonic TissuePlacentomePlayPositionPositioning AttributePre-Clinical ModelPreclinical ModelsPredispositionPregnancyProcessProphylactic vaccination against influenzaProteinsReassortant VirusesRegulationReportingResearchSeasonsSpecificitySusceptibilitySystems DevelopmentT-CellsT-LymphocyteTestingType A InfluenzaVaccinatedVaccinationVaccinesVirusWomen in adulthoodWorkadaptive immune responseage 6age 6 yearsanti-fluanti-influenzaantibody transferantiflubefore conceptiondevelopmentalflu immunisationflu infectionflu serotypeflu strainflu subtypeflu vaccineflu viral strainflu virus infectionflu virus strainflu virus vaccinehigh riskhost responsehuman modelimmune response to vaccinationimmune response to vaccinesimmune system responseimmunogenimmunoresponseinfancyinfantileinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfluenza infectioninfluenza serotypeinfluenza straininfluenza subtypeinfluenza viral straininfluenza virus infectioninfluenza virus straininfluenza virus vaccinationinfluenza virus vaccineinfluenzavirusinnovateinnovationinnovativeinsightmaternal immunizationmaternal vaccinationmodel of animalmodel of humannano particlenano-sized particlenanoparticlenanosized particlenewborn childnewborn childrennon-human primatenonhuman primatenonhuman primate modelspan influenza vaccinepan influenza viral vaccinepan influenza virus vaccineplacental transferpreconceptionprior to conceptionresponsesix year oldsix years of agestemthymus derived lymphocyteuniversal flu vaccineuniversal influenza vaccineuniversal influenza virus vaccineuniversal vaccineuniversal vaccine against fluuniversal vaccine against influenzavaccination against influenzavaccine against fluvaccine against influenzavaccine associated immune responsevaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccine responsevaccine responsivenessvaccine-induced response
Description preview
Young infants are at high risk for severe disease following influenza virus infection. The current
strategy for protecting infants is to increase antibody in the mother that can be transferred
across the placenta to the fetus such that infants are born with influenza virus-specific
antibodies on board. However, while maternal antibodies can…
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