grant

The INICIO-Guatemala Study: Improving Neurodevelopment with an Intestinal Health and Caregivers’ Intervention in the Occidente, Guatemala

Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 9 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20250-11 years oldAccelerationAge MonthsAmino AcidsAnemiaBiological MarkersCare GiversCare giver interventionCaregiver instructionCaregiversCentral AmericaChildChild MortalityChild YouthChildren (0-21)ChronicClinicalDataDevelopmentDiarrheaDietary InterventionDiscipline of NursingDysfunctionEnrollmentEnteralEntericEspanolEssential Amino AcidsFe elementFiberFolateFolic AcidFoodFosteringFunctional disorderFutureGeneralized GrowthGoalsGrowthGuatemalaGuatemalanHealthHigh PrevalenceHumanImpoverishedIncidenceIndian CornIndividualInfantInflammationInternationalInterventionIntervention StudiesIntestinalIntestinesInvestigatorsIronLeadLearningLifeLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMaizeMalnutritionMeasuresMicronutrientsModern ManMothersNeural DevelopmentNeurologicNeurologicalNon-digestible FibersNursingNursing FieldNursing ProfessionNutrientNutritionNutrition InterventionsNutritional DeficiencyNutritional InterventionsOutcomePanamaPb elementPerformancePermeabilityPhysiopathologyPhytochemicalPlayPovertyProductivityPropertyProteinsPsychologyPteroylglutamic AcidQOCQuality of CareRandomizedRandomized, Controlled TrialsRecommendationResearchResearch InstituteResearch PersonnelResearchersResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingRiceRiskRuralSiteSpanishStudentsSupplementationSystemTestingTimeTissue GrowthTrainingTranslationsUndernutritionUniversitiesVitamin MVitaminsWorkWorld Health OrganizationZincZn elementactive control groupaminoacidbeanbio-markersbiologic markerbiomarkerbowelcare giver educationcare giver instructioncare giver trainingcare givingcareercareer developmentcaregiver educationcaregiver interventionscaregiver trainingcaregivingdesigndesigningdevelopmentaldiagnostic tooldiet interventiondietary deficiencyearly childhoodenrollheavy metal Pbheavy metal leadhigh riskimprovedintervention researchinterventional researchinterventional studyinterventions researchkidsmalnourishedmeetingmeetingsmembermultidisciplinaryneurodevelopmentnew diagnosticsnext generation diagnosticsnovelnovel diagnosticsnutrition deficiencynutrition deficiency disordernutritional deficiency disordernutritional supplementationontogenypathophysiologyplant compoundplant derived compoundprebiotic fibersprebioticspreventpreventingprimary outcomepsychosocialrandomisationrandomizationrandomized control trialrandomly assignedrapid growthsecondary outcomestudent researchstudent-led researchtranslationvitamin Bcyoungster
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ABSTRACT
Child neurodevelopment (ND) is significantly impacted by nutrition in early life, a time of rapid growth and intricate

development of the neurological system. In low resource settings, we now know that meeting nutrient

recommendations alone is not enough to support optimal child growth and ND—a key driver of malnutrition and

poor ND is…

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