grant
The impact of shigellosis and recommended treatment in children
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 2 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20250-11 years oldActive Follow-upAcuteAddressAffectAfricaAgeAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAsiaAssayAzadoseAzithromycinAzitrocinAzythromycinBacillary DysenteryBangladeshBioassayBiologicalBiological AssayBloodBlood Reticuloendothelial SystemBlood SampleBlood specimenBloody diarrheaChildChild YouthChildren (0-21)CholeraChronicClinicalClinical TrialsCognitiveCollaborationsControlled Clinical TrialsCountryDetectionDevelopmentDiagnostic testsDiarrheaDoseDysenteryEmesisEnrollmentFecesFeverFrequenciesFutureGeneralized GrowthGrowthHealth Care FacilityHealth FacilitiesHealth systemHemorrhagic colitisHemorrhagic diarrheaHome visitationHospital AdmissionHospitalizationHospitalsHouse CallImpairmentImpoverished AreasImpoverished RegionsInfectionInfectious Diarrheal DiseaseInflammationInflammatoryInpatientsInterventionIntestinalIntestinesInvadedKineticsLengthLifeLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMalnutritionMiscellaneous AntibioticMorbidityMorbidity - disease rateMucosaMucosal TissueMucous MembraneNatureNorthern RhodesiaNutritional DeficiencyOutcomePathologyPatientsPerformancePhasePlacebo ControlPlacebosPoliciesPoverty AreasPoverty RegionsPrimary Health CareProcessProviderProxyPyrexiaRandomizedRapid diagnosticsRecommendationResearch ResourcesResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingResourcesRuralSeveritiesSeverity of illnessSham TreatmentShigellaShigella DysenteryShigella InfectionsSpecific qualifier valueSpecifiedTestingTimeTissue GrowthUltreonUndernutritionVomitingWeightWorld Health OrganizationZambiaZithromaxZitromaxacceptability and feasibilityactive followupagesbacterial disease treatmentbacterial infectious disease treatmentbiologicbowelbowel inflammationcare facilitiescostdeath riskdetection testdetection testsdevelopmentaldietary deficiencydisease durationdisease lengthdisease severityenrollevidence basefebrilefebrisfecal samplefield based datafield learningfield studyfield testfollow upfollow-upfollowed upfollowupgut healthgut inflammationhome visitillness lengthimprovedinflamed bowelinflamed gutinflamed intestineintestinal epitheliumintestinal inflammationkidsmalnourishedmortalitymortality risknovelnutrition deficiencynutrition deficiency disordernutritional deficiency disorderontogenyplacebo controlledplacebo grouppoverty stricken areasprimary outcomeprospectiverandomisationrandomizationrandomized placebo-controlled clinical trialrandomized, clinical trialsrandomly assignedrapid assayrapid testrapid testssham groupsham therapyshigellosisstoolstool samplestool specimensystemic inflammationsystemic inflammatory responsetertiary caretreatment guidelinesweightsyoungster
Description preview
ABSTRACT
Shigella is a primary cause of moderate-to-severe diarrhea in children living in impoverished areas of the world.
Shigella is known for causing dysentery (blood in the stool). However, majority of the children infected with
Shigella present with watery diarrhea. The current World Health Organization (WHO) guidelines for treatment of…
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