grant
The impact of inherited and modifiable risk factors on clonal hematopoiesis and age-related disease
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AD dementiaActive Follow-upAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease riskAlzheimers DementiaAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAutomobile DrivingBehaviorBiologicalBiologyBlood PlasmaBlood Precursor CellCardiovascular DiseasesCause of DeathCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeChronicClonal expansion of hematopoietic cellsClonal expansion of hematopoietic stem cellsClonal hematopoietic expansionCognitionDNA mutationDeathDevelopmentDietDiseaseDisease OutcomeDisease ProgressionDisorderElderlyEquilibriumEvolutionFollow-Up StudiesFollowup StudiesGenetic ChangeGenetic defectGenetic mutationGoalsHealth Care ProfessionalHealth ProfessionalHematopoiesisHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic stem cellsHereditaryHumanImmuneImmune RegulatorsImmunesImmunomodulatorsIndividualInflammationInflammatoryInheritedIntracellular Communication and SignalingLifeLife CycleLife Cycle StagesLife StyleLifestyleLong-term Follow-upLongitudinal StudiesMeasurementMeasuresMediatingMendelian randomizationModern ManMutateMutationObesityOutcomeParticipantPathway interactionsPhenotypePlasmaPlasma ProteinsPlasma SerumPre-Clinical ModelPreclinical ModelsPredicting RiskPreventative strategyPrevention strategyPreventive strategyPrimary Senile Degenerative DementiaProspective cohortProteinsProteomicsResearchReticuloendothelial System, Serum, PlasmaRiskRisk FactorsSamplingSignal TransductionSignal Transduction SystemsSignalingSmokingSubcellular ProcessTestingUnited StatesWorkactive followupadiposityadjudicationadjudicative process and procedureadvanced ageadverse consequenceadverse outcomeage associatedage associated diseaseage associated disorderage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentalzheimer riskbalancebalance functionbiobankbiologicbiological signal transductionbiorepositoryblood cell formationblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcardiovascular disease riskcardiovascular disordercardiovascular disorder riskclonal expansions in the bloodclonal hematopoiesisclones in hematopoietic cellscohortcorpulencedevelopmentaldietsdisabilitydrivingfitnessfollow upfollow-upfollowed upfollowupforecasting riskgenome mutationgeriatrichealthy aginghealthy human aginghematopoietic cell cloneshematopoietic progenitorhematopoietic stem cell clonalityhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellimmune modulatorsimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimprovedindividualized preventionlack of physical activitylarge scale datalarge scale data setslarge scale datasetslife courselong-term followuplong-term studylongitudinal outcome studiesmalleable riskmid lifemid-lifemiddle agemiddle agedmidlifemodifiable risknew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypersonalized preventionphysical inactivityprecision preventionpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskprematureprematuritypreventpreventingprimary degenerative dementiarisk predictionrisk predictionssenile dementia of the Alzheimer typesenior citizenunhealthy lifestyle
Description preview
ABSTRACT
The goal of this proposal is to improve our understanding of the factors that drive clonal hematopoiesis
(CH) evolution to prevent CH-related adverse outcomes and promote healthy aging. CH is common with
aging. Most mutations are present in a small proportion of hematopoietic stem cells (HSCs). Yet in some
individuals, the proportion of…
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