grant
The impact of hormonal modulation on systemic inflammation and central sensitization
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 20 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AffectAfter CareAfter-TreatmentAftercareAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAntinociceptive AgentsAntinociceptive DrugsAquadiolAttenuatedBiologyBrainBrain Nervous SystemCNS Nervous SystemCentral Nervous SystemChronic pain syndromeClinicalClinical TrialsComplexDataDimenformonDiogynDiogynetsDiseaseDisorderDisproportionate number of femalesDisproportionate number of womenDisproportionately affects femalesDisproportionately affects womenDisproportionately impacts femalesDisproportionately impacts womenDisproportionately in femalesDisproportionately in womenDoseDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDrugsEconomicsEncephalonEndocrine Gland SecretionEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineEstrogensEvaluationFDA approvedFatigueFollicle Stimulating Hormone-Releasing Hormone ReceptorsFunctional MRIFunctional Magnetic Resonance ImagingGnRH ReceptorsGonadoliberin ReceptorsGonadorelin ReceptorsGonadotropin-Releasing Hormone ReceptorGynecologicHormonalHormonesHypersensitivityHysterectomyInflammationInflammatoryInterstitial CystitisInterventionInvestigatorsIrritable Bowel SyndromeIrritable ColonLHRH ReceptorsLack of EnergyLesionLuliberin ReceptorsLuteinizing Hormone Releasing-Hormone ReceptorMeasuresMediatingMedicalMedicationMigraineMigraine HeadacheMucous ColitisNeuraxisNeurobiologyOutcomeOvocyclinOvocylinPainPainfulPathway interactionsPatientsPelvicPelvic PainPelvic RegionPelvisPeripheralPharmaceutical PreparationsPhenotypePlacebosPositionPositioning AttributeProgynonRandomizedReproductive BiologyResearch PersonnelResearchersRisk FactorsSeveritiesSeverity of illnessSham TreatmentStimulusSymptomsTestingTherapeutic EstradiolTherapeutic EstrogenTherapeutic HormoneTreatment outcomeUnited StatesVulnerable PopulationsWomanWorkantagonismantagonistassociated symptomattenuateattenuatesbladder pain syndromecentral sensitizationchronic pelvic floor painchronic pelvic painchronic pelvic pain syndromeclinical phenotypeclinical practiceco-morbidco-morbid symptomco-morbidityco-occuring symptomcomorbid symptomcomorbidityconcurrent symptomcooccuring symptomcostdisease modeldisease severitydisorder modeldosagedrug/agenteconomicendometriosisexperiencefMRIfemale biasfemale predominancefemale preponderanceimprovedneurobiologicalneurobiological mechanismpain killerpain medicationpain modelpain reliefpain relieverpainful bladder syndromepainkillerpathwaypelvic myofascial painpost treatmentpredict responsivenesspredicting responsepredominance in femalespredominance in womenrandomisationrandomizationrandomized placebo-controlled clinical trialrandomized, clinical trialsrandomly assignedrecruitrelieve painresponsesham therapyspastic colonsymptom associationsymptom comorbiditysystemic inflammationsystemic inflammatory responsetreatment effecttreatment strategyvulnerable groupvulnerable individualvulnerable peoplewomen's predominancewomen's preponderance
Description preview
Abstract. Chronic pelvic pain remains a challenging condition to treat, in large part because underlying
disease mechanisms are poorly understood. Endometriosis-associated pelvic pain (EAPP) is a common form
of CPP wherein the severity of disease is only weakly associated with the degree of pain experienced. While
pelvic inflammation is a…
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