grant
The Impact of Bile Salt Hydrolase on Intestinal T Cells in Colitis
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 26 Mar 2026Deadline 25 Mar 2029
NIHUS FederalResearch GrantFY202621+ years oldAddressAdultAdult HumanAffectAmino AcidsAnimal ModelAnimal Models and Related StudiesBacteriaBile AcidsCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCausalityCecumChemicalsColitisColonCommunicationCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDSS colitisDSS modelDSS mouse modelDSS-induced acute colitisDSS-induced colitisDataDevelopmentDevelopment PlansDevelopment and ResearchDiseaseDisorderE coliE. coliEngineeringEnzyme GeneEnzymesEscherichia coliEtiologyExperimental DesignsFluorescence Activated Cell Sorting FractionationFluorescence-Activated Cell SortingFluorescence-Activated Cell SortingsGI microbiomeGI microbiotaGastrointestinal microbiotaGoalsHistologicHistologicallyHydrolaseHydrolase Family GeneHydrolase GeneIL-17IL-17 GeneIL-17AIL-17A GeneIL17IL17 ProteinIL17 geneIL17AIL17A GeneImmuneImmune responseImmune systemImmunesImmunomodulationImmunosuppressantsImmunosuppressive AgentsImmunosuppressive drugImmunosuppressive treatmentIn VitroInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17IntestinalIntestinesInvestigatorsKnowledgeLactobacillusLamina PropriaLinkMeasuresMediatingMentorshipMiceMice MammalsMicrobeModelingMurineMusOutcome StudyPathogenesisPatientsPhylogenetic AnalysisPhylogeneticsPopulationProductionPublic HealthR & DR&DReceptor ProteinResearchResearch PersonnelResearchersScientistSeriesSeveritiesSignaling MoleculeT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTrainingadulthoodamidationaminoacidbile saltsbowelcareer developmentcareer faircareer networkingcausationcolitis-induced dysbiosiscommensal floracommensal microbescommensal microbiotacommensal microfloradevelopmentaldextran sulfate sodium colitisdextran sulfate sodium induced colitisdextran sulfate sodium modeldextran sulfate sodium mouse modeldigestive tract microbiomedisease causationenteric microbial communityenteric microbiomeenteric microbiotagastrointestinal microbial floragastrointestinal microbiomegut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehost microbiomehost responseimmune modulationimmune regulationimmune suppressive agentimmune suppressorimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive substanceimmunosuppressorin vivoinflammatory disease of the intestineinflammatory disorder of the intestineinnovateinnovationinnovativeinsightintestinal autoinflammationintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloramanage symptommeetingmeetingsmetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial consortiamicrobial floramicrobiomemicrobiotamicrofloramodel of animalmultispecies consortianew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoverexpressoverexpressionpreferenceprofessional networkingprotective effectreceptorresearch and developmentskill acquisitionskill developmentspeed networkingsymptom managementthymus derived lymphocytetooltranslational impact
Description preview
PROJECT SUMMARY/ABSTRACT
Inflammatory bowel disease (IBD) affects up to 3.1 million adults in the U.S. Bile acids are recognized as
key signaling molecules in microbe-immune communication and may therefore be new therapeutic targets for
IBD. Microbes deconjugate bile acids with bile salt hydrolases (BSHs), which can produce a variety of bacterial…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click