grant
The impact of alcohol and its metabolites on the epigenome of astrocytes
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025Absolute ethanolAcetate ThiokinaseAcetate-CoA LigaseAcetatesAcetothiokinaseAcetyl Activating EnzymeAcetyl CoAAcetyl CoA SynthetaseAcetyl Coenzyme AAcetyl Coenzyme A SynthetaseAddressAffectAgreementAlcohol Chemical ClassAlcohol-Induced NeurotoxicityAlcoholsAstrocytesAstrocytusAstrogliaBehaviorBiologicalBrainBrain Nervous SystemCNS Nervous SystemCell Communication and SignalingCell NucleusCell SignalingCell-Extracellular MatrixCentral Nervous SystemChromatinComplexDNADataDeoxyribonucleic AcidDepositDepositionDiseaseDisorderDrug TherapyECMETOHEncephalonEnhancersEnvironmental FactorEnvironmental Risk FactorEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthanolEthanol MetabolismEthyl AlcoholExtracellular MatrixGene Action RegulationGene ActivationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGliaGlial CellsGrain AlcoholHistone AcetylaseHistone AcetylationHistonesHourImmediate-Early GenesIn vivo analysisIntermediary MetabolismIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeKolliker's reticulumLabelMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMetabolicMetabolic ProcessesMetabolismMethylcarbinolMiceMice MammalsModelingMonitorMotivationMurineMusNIAAANational Institute on Alcohol Abuse and AlcoholismNatureNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeurogliaNeuroglial CellsNeuronsNon-neuronal cellNonneuronal cellNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesNucleusNull MousePathway interactionsPatientsPharmacological TreatmentPharmacotherapyProcessPropertyProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqRegulationRegulatory RegionsRoleS-acetate Coenzyme ASignal TransductionSignal Transduction SystemsSignalingStimulusStructural GenesSynaptic plasticitySystemTestingTherapeuticTimeTranscriptionTranscription AlterationTransmissionUpregulationWorkalcohol behavioralcohol exposedalcohol exposurealcohol induced behavioralcohol metabolismalcohol related behavioralcohol use disorderastrocytic gliabiologicbiological signal transductionburden of diseaseburden of illnesscell typedisease burdendrug interventiondrug treatmentenvironmental riskepigeneticallyepigenomeethanol behaviorethanol exposedethanol exposureethanol induced behaviorethanol related behaviorethanol use disorderethanol-induced neurotoxicityexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolfascinatefear memorygenetic regulatory elementhistone acetyltransferasein vivoin vivo evaluationin vivo testinginhibitorinsightknock-downknockdownmouse modelmurine modelnerve cementneuronalnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetpathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspromoterpromotorresponsesocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstructural genetranscriptome sequencingtranscriptomic sequencingtransmission processuptake
Description preview
PROJECT SUMMARY
Alcohol use disorder (AUD) is a global disease burden and while biological mechanisms underlying AUD have
largely been examined in neurons, the role of glial cells is historically understudied. One glial cell type potentially
important in AUD is astrocytes, which undergo transcriptional and functional changes upon alcohol exposure.…
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