grant
The immunobiological mechanisms of depression in perimenopause
Organization VAN ANDEL RESEARCH INSTITUTELocation GRAND RAPIDS, UNITED STATESPosted 20 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20252,3,7,8-Tetrachlorodibenzo-p-dioxin ReceptorsAH ReceptorsATAC sequencingATAC-seqATACseqAffectAgeAryl Hydrocarbon ReceptorAssay for Transposase-Accessible Chromatin using sequencingAstrocytesAstrocytusAstrogliaBasal Transcription FactorBasal transcription factor genesBiologicalBiological MarkersBlood CellsBlood PlasmaBlood SampleBlood specimenCNS Nervous SystemCell BodyCellsCentral Nervous SystemChromatinChronicClinical ResearchClinical StudyCorpus Luteum HormoneDNA MethylationDataDelta4-pregnene-3,20-dioneDepressed moodDevelopmentDioxin ReceptorsEmotional DepressionEndocrine Gland SecretionEndocrine TherapyEnrollmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEstrogensExhibitsFollow-Up StudiesFollowup StudiesFunding OpportunitiesFutureGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGonadal Steroid HormonesHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHigh Risk WomanHormonalHormonal ChangeHormonal TherapyHormone useHormonesHortega cellImmuneImmune RegulatorsImmune responseImmune systemImmunesImmunoassayImmunomodulationImmunomodulatorsInducer CellsInducer T-LymphocytesInflammationInflammatoryInflammatory ResponseKnowledgeL-TryptophanLevotryptophanLifeLigand BindingLigandsLinkLymphatic cellLymphocyteLymphocyticMediatingMenopausal StatusMental DepressionMetabolic MarkerMethylationMicrogliaMissionMolecularMolecular ConfigurationMolecular ConformationMolecular StereochemistryMoodsNIMHNational Institute of Mental HealthNational Institutes of HealthNeuraxisNuclear TranslocatorPBMCParticipantPatternPerimenopausalPerimenopausePeripheralPeripheral Blood CellPeripheral Blood Mononuclear CellPhysiologicPhysiologicalPlasmaPlasma SerumPlayPolyaromatic Hydrocarbon ReceptorsPopulationPositionPositioning AttributePost-Natal DepressionPost-Partum DepressionPostnatal DepressionPostpartum DepressionPostpartum PeriodPregn-4-ene-3,20-dionePregnenedioneProgesteronePsychosesRNA SeqRNA sequencingRNAseqRegulationRegulatory T-LymphocyteResearchReticuloendothelial System, Serum, PlasmaRiskRoleSex HormonesSex Steroid HormonesSiteSortingSymptomsT cell differentiationT cell responseT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsTCDD ReceptorsTestingTherapeutic EstrogenTherapeutic HormoneTherapeutic ProgesteroneTimeTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTregTryptophanUnited States National Institutes of HealthVisitWomanWorkagesahr ligandantenatal depressionantepartum depressionaryl hydrocarbon receptor ligandassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingastrocytic gliaat-risk femalesat-risk womenbio-markersbiologicbiologic markerbiomarkerbiomarker identificationchromatin modificationchromatin remodelingclinical diagnosticsconformationconformationalconformational stateconformationallyconformationscytokinedepresseddepressiondepression during pregnancydepression in pregnancydepression symptomdepressivedepressive symptomsdevelopmentaleffective therapyeffective treatmentenrollepigeneticallyfemales at high riskgitter cellgonadal steroidshigh riskhigh risk femaleshormone therapyhost responseidentification of biomarkersidentification of new biomarkersimmune modulationimmune modulatorsimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunomodulatory moleculesimmunoregulationimmunoregulatorimmunoregulatoryimmunoregulatory moleculesimmunoresponseimprovedinflammation markerinflammatory markerlymph cellmarker identificationmedical diagnosticmenopause transitionmesogliamethylation patternmicroglial cellmicrogliocytenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyperi-menopausalperi-menopauseperivascular glial cellpost-partumpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprenatal depressionprenatal depressive symptomsrecurrent depressionregulatory T-cellsresponsesadnesssex steroidsocial rolesuicidalsuicidalitysuicide ratethymus derived lymphocytetooltranscription factortranscriptome sequencingtranscriptomic sequencingtransition to menopausetransitional menopausewomen at high risk
Description preview
PROJECT SUMMARY/ABSTRACT
This project aims to identify immunobiological mechanisms underlying the development of depression during the
perimenopause, in response to the NIMH funding opportunity “Mood and Psychosis Symptoms during the
Menopause Transition”. During the perimenopause, the risk for recurrence of depression is increased 13-fold
among…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click