grant
The Hypothalamic Basis of Aging
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Feb 2010Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AgingAnimalsAreaAutonomic nervous systemAutoregulationBiochemicalBiological FunctionBiological ProcessBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell SignalingCell secretionCellsCellular SecretionCognition DisordersCommunicationDNA DamageDNA InjuryDataDegenerative Neurologic DisordersDiseaseDisorderDistantDrug TherapyEffectivenessEncephalonEndocrineEndocrine systemEndocrine/Metabolic Organ SystemEquilibriumEventExperimental ModelsFormulationFundingGenerationsGeneticHealthHomeostasisHormonalHormonal SystemHypothalamic structureHypothalamusImmunomodulationIn VitroInflammatoryIntermediary MetabolismInterventionIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceKnowledgeLength of LifeLongevityLow Molecular Weight Nuclear RNAMaintenanceMetabolicMetabolic ProcessesMetabolic/Endocrine Body SystemMetabolismMethodsModelingMolecularNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural Stem CellNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeuroendocrineNeuroendocrine SystemNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNeurosecretory SystemsNull MousePharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPlayProgenitor CellsPublicationsPublishingResearchRoleScientific PublicationSignal TransductionSignal Transduction SystemsSignalingSiteSmall Molecular Weight RNASmall Nuclear RNATherapeuticTherapeutic EffectVesicleaccelerated agingaccelerated biological ageaccelerated biological agingage accelerationage associatedage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage correlatedage dependentage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage linkedage relatedage related neurodegenerationage reversalage specificage-driven neurodegenerative disordersage-related neurodegenerative diseaseage-related neurodegenerative disorderaged brainaged miceaged mouseaging associatedaging associated diseaseaging associated disordersaging associated neurodegenerationaging associated neurodegenerative diseaseaging brainaging delayaging preventionaging relatedaging related diseaseaging related disordersaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderaging reversalalleviate age relatedalleviate agingameliorating aginganti aginganti geronicantiagingattenuate agingbalancebalance functionbiological signal transductioncell typecognitive diseasecognitive disordercognitive syndromecounter age relatedcounter agingcounteract age relatedcounteract agingdecelerate agingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdelay age relateddisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingdrug interventiondrug treatmentelderly miceendocrine gland/systemenhance healthspanexperimentexperimental researchexperimental studyexperimentsextend healthspanextending healthy lifespanextracellular vesiclesgene manipulationgenetic manipulationgenetically manipulategenetically perturbhealthspanhealthspan extensionhealthy aginghealthy human aginghealthy life spanhypothalamicimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimprove healthspanimprovedin vivoin vivo Modelincrease healthspanlife spanlifespanmouse modelmurine modelnatural agingnerve stem cellneuralneural degenerationneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurodegenerationneurodegenerativeneurodegenerative illnessneurodegenerative phenotypeneurogenic progenitorsneurogenic stem cellneurological degenerationneuron progenitorsneuronalneuronal degenerationneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitorneuroprotectionneuroprotectivenew approachesnormal agingnormative agingnovelnovel approachesnovel strategiesnovel strategyold micepause agingpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspostpone age relatedprevent age relatedprevent agingpro-agingprogenitor and neural stem cellsprogeronicprogramsprolong healthspanpromote agingpromote healthspanretards agingreverse agereverse agingreverse aging effectsreversible agingsenescencesenescentslow agingslow down agingslow the rate of agingsnRNAsocial rolestem cellssuppress agingtissue degenerationuRNAuptake
Description preview
ABSTRACT/SUMMARY
Aging is multifaceted while many hormonal and metabolic regulators are crucial, pointing to the extremely
strong significance of endocrine and metabolic processes in aging physiology and intervention. The
hypothalamus is the “headquarters” for regulating systemic endocrine systems and metabolic physiology as
well as the autonomic…
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