grant
The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function
Organization UNIVERSITY OF SOUTH FLORIDALocation TAMPA, UNITED STATESPosted 1 Apr 2011Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AD dementiaAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaBrainBrain Nervous SystemChaperoneCognitive deficitsDisease ProgressionEncephalonFK-506-Binding ProteinFK506 Binding ProteinsFK506 binding protein 5FKBPFKBP RotamaseFKBP51FKBP54Gene variantKnowledgeLinkMAPT geneMAPT proteinMT-bound tauMTBT1Mental DepressionMiceMice MammalsMolecularMolecular ChaperonesMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsPathogenesisPathway interactionsPatientsPrimary Senile Degenerative DementiaProteinsResearchRiskRisk-associated variantRoleStructureTacrolimus Binding ProteinsTauopathiesToxic effectToxicitiesTransgenic MiceWorkabnormally aggregated tau proteinallelic variantcognitive defectsdepressionfilamentous tau inclusiongenetic variantgenomic variantmicrotubule associated protein taumicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-associated protein taumicrotubule-bound taumouse modelmurine modelneuronalneuropathologic tauneuropathological tauneuropsychiatric symptompaired helical filament of taupathwayprimary degenerative dementiarisk allelerisk generisk genotyperisk locirisk locusrisk variantself-aggregate tausenile dementia of the Alzheimer typesocial roletacrolimus binding protein 5tautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau fibrillizationtau filamenttau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neurofibrillary tangletau neuropathologytau oligomertau paired helical filamenttau pathologytau pathophysiologytau polymerizationtau proteinopathytau related neurodegenerationtau-induced pathologytau-tau interactiontauopathic neurodegenerative disordertauopathyτ Proteinsτ aggregation
Description preview
Project Summary/Abstract
Neuropsychiatric symptoms (NPS), like depression, are common early in Alzheimer’s disease (AD) and
correlate with a faster decline in patients. NPS and cognitive deficits in AD have been linked with the
accumulation of tau protein. Two independent studies associated an allelic variant in the 51kDa FK506-binding
protein…
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