grant
The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function
Organization UNIVERSITY OF SOUTH FLORIDALocation TAMPA, UNITED STATESPosted 1 Apr 2011Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AD dementiaAblationAffectAffective DisordersAffective SymptomsAgingAllelesAllelomorphsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's brainAlzheimer's disease brainAlzheimer's disease patientAlzheimer's patientAlzheimers DementiaAttenuatedBehavior assessmentBehavioralBiologyBrainBrain Nervous SystemChaperoneCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalDataDisease ProgressionDisturbance in cognitionDysfunctionElectrophysiologyElectrophysiology (science)EncephalonFK-506-Binding ProteinFK506 Binding ProteinsFK506 binding protein 5FKBPFKBP RotamaseFKBP51FKBP54Functional disorderGene variantGoalsHealthImmediate MemoryImmune responseImpaired cognitionImpairmentIn VitroIntermediary MetabolismKO miceKnock-out MiceKnockout MiceKnowledgeLinkMAPT geneMAPT proteinMT-bound tauMTBT1MediatingMental DepressionMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaModelingMolecularMolecular ChaperonesMood DisordersMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNull MouseObesityOutcomePathogenesisPathologicPathway interactionsPatientsPhysiopathologyPoly QPrimary Senile Degenerative DementiaProteinsProteomicsResearchRespirationRiskRisk-associated variantRoleShort-Term MemorySingle Base PolymorphismSingle Nucleotide PolymorphismStressStructureSynapsesSynapticSynaptic plasticitySynaptosomesTacrolimus Binding ProteinsTauopathiesTestingTherapeutic Steroid HormoneToxic effectToxicitiesTransgenic MiceVariantVariationWorkabnormal tauabnormally aggregated tau proteinadiposityaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationallelic variantattenuateattenuatesbehavioral assessmentcognitive defectscognitive dysfunctioncognitive losscorpulencedepressionelectrophysiologicalexcitatory neuronfilamentous tau inclusiongenetic variantgenomic varianthormonal signalshormone signalshost responseimmune system responseimmunoresponsein vivoinhibitorinsightknock-downknockdownmicrotubule associated protein taumicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule associated protein tau mutationmicrotubule bound taumicrotubule-associated protein taumicrotubule-associated protein tau mutationmicrotubule-bound taumitochondrialmitochondrial dysfunctionmouse developmentmouse modelmurine modelmutant taumutation in microtubule associated protein taumutation in microtubule-associated protein taunerve cell deathnerve cell lossneuron cell deathneuron cell lossneuron deathneuron lossneuron toxicityneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossneuronal toxicityneuropathologicneuropathologic tauneuropathologicalneuropathological tauneuropathologyneuropsychiatric symptomneurotoxicneurotoxicityp-taup-τpaired helical filament of taupathogenic taupathogenic tau gene mutationpathological change in taupathophysiologypathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasephospho-tauphospho-τphosphorylated taupolyQpolyglutaminepopulation agingpost-translational modification of tauposttranslational modification of tauprimary degenerative dementiaresilienceresilientrespiratory mechanismrisk allelerisk generisk genotyperisk locirisk locusrisk variantself-aggregate tausenile dementia of the Alzheimer typesingle nucleotide variantsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssteroid hormonesynapsesynaptoneurosometacrolimus binding protein 5tautau PHFtau Proteinstau abnormalitytau accumulationtau aggregatetau aggregationtau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau fibrillizationtau filamenttau induced degenerationtau induced neurodegenerationtau intronic mutationtau mediated neurodegenerationtau mutationtau neurodegenerative diseasetau neurofibrillary tangletau neuropathologytau oligomertau paired helical filamenttau pathological changetau pathologytau pathophysiologytau phosphorylationtau polymerizationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytau-tau interactiontauopathic neurodegenerative disordertauopathytranscriptomicsworking memoryτ Proteinsτ aggregationτ mutationτ phosphorylation
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Project Summary/Abstract
Neuropsychiatric symptoms (NPS), like depression, are common early in Alzheimer’s disease (AD) and correlate
with a faster decline in patients. NPS and cognitive deficits in AD have been linked with the accumulation of tau
protein. Two independent studies associated an allelic variant in the 51kDa FK506-binding protein…
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