grant
The functions of the claustrum in flexible decision making.
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 24 Mar 2026Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026AD/HDADHDASDAction PotentialsAffectAnatomic SitesAnatomic structuresAnatomyAnimalsAreaAttention deficit hyperactivity disorderAutismAutistic DisorderBehaviorBehavioralBrainBrain Nervous SystemCell NucleusCerebral cortexClaustral structureClaustrumCognitiveCorpus StriatumCorpus striatum structureDataDecision MakingDiseaseDisorderEarly Infantile AutismEncephalonExhibitsFutureHealthImpairmentInfantile AutismKanner's SyndromeLateralLearningLesionMapsMedialMental disordersMental health disordersMiceMice MammalsModelingMurineMusNeocortexNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesNucleusOutcomeOutputPathway interactionsPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPrefrontal CortexProbabilityPropertyPsychiatric DiseasePsychiatric DisorderPsychological reinforcementReinforcementReversal LearningRewardsRoleSchizophreniaSchizophrenic DisordersSensoryStimulusStriate BodyStriatumStructureSynapsesSynapticSystemTask PerformancesTestingThalamic structureThalamusTransmissionautism spectral disorderautism spectrum disorderautistic spectrum disorderbehavior responsebehavioral responsecell typecognitive controldementia praecoxexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblefrontal cortexfrontal lobehomotypical cortexisocortexmental illnessneopalliumneuralneural circuitneural circuitryneural mechanismneural modelneurocircuitryneuromechanismneuronalneuropsychiatric diseaseneuropsychiatric disorderpathwaypsychiatric illnesspsychological disorderresponseschizophrenicsocial rolestriatalsynapsesynaptic circuitsynaptic circuitrythalamictheoriestransmission process
Description preview
PROJECT SUMMARY:
Cognitive flexibility is disrupted in many neuropsychiatric diseases, but how the brain generates flexible
behavior is not fully understood. Learning from recent actions requires neural mechanisms that maintain
information about relevant decision variables to influence future decisions. Persistent activity in cortical areas…
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