grant
The Evolution of Gene Regulation and Human Disease
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Apr 2018Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AddressAfricaAllelesAllelomorphsAreaBasic ResearchBasic ScienceBiologyChromosome MappingClinicalCodeCoding SystemComputing MethodologiesDNADNA SequenceDNA mutationDeoxyribonucleic AcidDiseaseDisorderEvolutionFundingGene Action RegulationGene ExpressionGene Expression RegulationGene LocalizationGene MappingGene Mapping GeneticsGene RegulationGene Regulation ProcessGene variantGenesGenetic ChangeGenetic DiversityGenetic RiskGenetic VariationGenetic defectGenetic mutationGenomeGrantHistoryHumanIndividualLinkage MappingMachine LearningManuscriptsMethodsMissionModelingModern ManMutationNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesPatientsPatternPersonsPhenotypePopulationPositionPositioning AttributePreventative carePreventive careRecording of previous eventsRegulatory ElementRegulatory RegionsRiskShapesSourceTechnologyTestingTotal Human and Non-Human Gene MappingTransgenesVariantVariationWorkallelic variantcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methoddisease riskdisorder riskflexibilityflexiblefunctional genomicsgenetic mappinggenetic regulatory elementgenetic variantgenome mutationgenomic datagenomic datasetgenomic varianthistorieshuman diseasemachine based learningmachine learning based methodmachine learning methodmachine learning methodologiesmolecular phenotypeprogramssuccesstraittransgenetrend
Description preview
PROJECT SUMMARY
The long-term mission of my lab is to accurately model the effects of DNA sequence differences between indi-
viduals on phenotypes relevant to disease and human evolution. Genetic variants that modify gene regulation
are major contributors to both evolutionary divergence between species and differences in risk for disease
among…
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