grant

The Epigenetics of Cytoplasmic Incompatibility

Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 7 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026A. aegyptiAblationAbscissionAcetylationAdes aegyptiAe. AegyptiAedes aegyptiArboviralArboviral infectionsArbovirus InfectionsArbovirusesArthropod-Born Viral InfectionArthropod-Borne VirusesArthropodaArthropodsAutomobile DrivingBacteriaBiologicalBreakbone Fever VirusCell NucleusChemicalsChromatinCommunitiesComplementComplement ProteinsCountryCoupledCulicidaeCytoplasmDENVDNADataDefectDengueDengue VirusDengue fever virusDeoxyribonucleic AcidDepositDepositionDevelopmentDrosophila melanogasterEmbryoEmbryo DeathsEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEngineeringEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventExcisionExtirpationFecundabilityFecundityFemaleFertilityFertilizationFliesFrequenciesGametogenesisGene TranscriptionGenesGeneticGenetic TranscriptionGenetic studyGenomeHistone AcetylaseHistone AcetylationHistonesHumanImpairmentIndividualInsectaInsectsInsects InvertebratesInvestigationKnock-outKnockoutLinkMeasuresMethylationModern ManModificationMolecularMorphologyMosquito-borne diseaseMosquito-borne infectious diseaseMosquitoesNucleusOogenesisOvaryPartner in relationshipPathogenicityPlayPopulationPopulation SizesPost-Transcriptional Gene SilencingProcessProphagesProtaminesProteinsRNA ExpressionRNA InterferenceRNA SilencingRNA VirusesRNAiRemovalResearchResistanceRoleSequence-Specific Posttranscriptional Gene SilencingSexual ReproductionSpecific qualifier valueSpecifiedSpermSpermatidsSpermatoblastsSpermatozoaSpermiogenesisSurgical RemovalSystemTesticlesTestingTestisTimeTranscriptTranscriptionTransgenic OrganismsTransmissionUbiquitilationUbiquitinationUbiquitinoylationVariantVariationViralWolbachiaZIKVZika Virusarthropod-borne infectionarthropodborne infectionbiologiccomplementationcost effectivedevelopmentaldrivingeggepigenetic regulationepigeneticallyexperimentexperimental researchexperimental studyexperimentsfemale infectionsfertilizationsflygenome integritygenomic integrityhistone acetyltransferasehistone modificationinfected femalesinfected womeninfections among womeninfections in femalesinfections in womeninterestknock-downknockdownmalematemutantoverexpressoverexpressionprogramsresectionresistantsexsocial rolesperm cellspermidspermoblastsuccesstooltraittransgenictransmission processubiquinationubiquitin conjugationvector controlwomen experiencing infectionswomen infectionswomen with infectionszikavzoosperm
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Project Summary:
Wolbachia are a genus of endosymbiotic bacteria that comprise a promising, cost-effective tool to curb arboviral

transmission based on two key facets. First, Wolbachia block pathogenic RNA viruses by inhibiting their

replication in arthropods. Second, Wolbachia selfishly alter sperm and egg via a process termed cytoplasmic…

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The Epigenetics of Cytoplasmic Incompatibility — PENNSYLVANIA STATE UNIVERSITY, THE | UNITED STATES | May 2024 | Dev Procure