grant
The effects of synaptically released zinc on neuronal processing and brain function
Organization WEST VIRGINIA UNIVERSITYLocation MORGANTOWN, UNITED STATESPosted 1 Aug 2020Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025ASDAmmon HornAutismAutistic DisorderAxon TerminalsBasal GangliaBasal NucleiBehavioralBrainBrain Nervous SystemBrain regionCarrier ProteinsCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCornu AmmonisDNA mutationDisturbance in cognitionEarly Infantile AutismEncephalonGenetic ChangeGenetic defectGenetic mutationGlutamatesHippocampusHumanImpaired cognitionIndividualInfantile AutismIntracellular Communication and SignalingKO miceKanner's SyndromeKnock-out MiceKnockout MiceL-GlutamateLaboratoriesLeadLinkModern ManMolecularMutationNerve CellsNerve Transmitter SubstancesNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeural TransmissionNeurocyteNeurologic DisordersNeurological DisordersNeuronsNeurotransmittersNull MousePathologicPb elementPopulationPresynaptic Nerve EndingsPresynaptic TerminalsRoleSLC30A3SLC30A3 geneSchizophreniaSchizophrenic DisordersSensorySensory impairmentShapesSightSignal TransductionSignal Transduction SystemsSignalingSolute Carrier Family 30 (Zinc Transporter), Member 3StructureSubcellular ProcessSynapsesSynapticSynaptic BoutonsSynaptic ReceptorsSynaptic TerminalsSynaptic TransmissionSynaptic VesiclesTransport Protein GeneTransport ProteinsTransporter ProteinVisionZNT3ZincZinc Transporter 3Zn elementautism spectral disorderautism spectrum disorderautistic spectrum disorderbiological signal transductionbrain cellcartilage link proteincognitive dysfunctioncognitive lossdementia praecoxgenome mutationglutamatergicheavy metal Pbheavy metal leadhippocampalimprovedinsightlink proteinneuralneural controlneural regulationneurological diseaseneuromodulationneuromodulatoryneuronalneuroregulationpostsynapticpresynapticschizophrenicsocial rolesynapsevisual functionzinc binding ligandzinc transporterzinc-binding protein
Description preview
Project Abstract
Many regions of the brain including the cortex, hippocampus, basal ganglia, and limbic structures are highly
enriched with synaptic zinc. Synaptic zinc (as Zn2+) is loaded into presynaptic vesicles by zinc transporter 3
(ZnT3), where it is coreleased with glutamate during synaptic transmission. Synaptic zinc can modulate many…
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