grant
The effect of right dlPFC cTBS on acute measures of anxiety, functional connectivity, and TMS-evoked BOLD responses
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Apr 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AcuteAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnteriorAnxietyAnxiety DisordersArousalBOLD responseBed Nucleus of Stria TerminalisBehavioralBrainBrain Nervous SystemBrain regionCirculatory CollapseCross-Over DesignsCrossover DesignDataDevelopmentDiseaseDisorderDoseDown-RegulationElectromyographyEncephalonFearFrightFunctional MRIFunctional Magnetic Resonance ImagingFutureHeadInvestigatorsLiliumLilyLinkMeasuresMental DepressionModelingOutcomePTSDPatientsPeriodicalsPhenotypePhysiologic pulsePost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPrefrontal CortexProtocolProtocols documentationPsychopathologyPulseRegulationResearch PersonnelResearchersRestRunningScanningShockSiteStandardizationStria Terminalis NucleusStructureStructure of terminal stria nuclei of preoptic regionSurfaceSymptomsTechnologyTherapeuticTranscranial magnetic stimulationTreatment ProtocolsTreatment RegimenTreatment Scheduleabnormal psychologyamygdaloid nuclear complexanxiety reductionanxiety treatmentanxiousanxious individualsassess effectivenessbehavior measurementbehavior outcomebehavioral measurebehavioral measurementbehavioral outcomeblood oxygenation level dependent responsecingulate cortexcirculatory shockdepressiondetermine effectivenessdevelopmentaleffectiveness assessmenteffectiveness evaluationelectric fieldemotional expressionevaluate effectivenessexamine effectivenessexpression of emotionfMRIhigh definitionhigh-resolutionindexinginnovateinnovationinnovativeneuralneural controlneural mechanismneural regulationneuromechanismneuromodulationneuromodulatoryneuroregulationnovelpatient populationperiodicperiodicalpost-trauma stress disorderposttrauma stress disorderprimary outcomepublic health relevanceresponseshocksshowing emotiontherapy optimizationtraittraumatic neurosistreatment centertreatment optimization
Description preview
The right dorsolateral prefrontal cortex (dlPFC) is increasingly being targeted with transcranial magnetic
stimulation (TMS) to reduce anxiety expression in anxiety disorders, depression, and posttraumatic stress
disorder (PTSD). There seems to be clear mechanistic evidence that right dlPFC downregulation of amygdala
activity should reduce fear…
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