grant
The Effect of Exercise on T Cell Aging in Rheumatoid Arthritis
NIHUS FederalResearch GrantFY202565 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAddressAdherenceAerobic ActivityAerobic ExerciseAerobic TrainingAerobic fitnessAged 65 and OverAgingAssayAtrophic ArthritisBioassayBiological AgingBiological AssayCaloric RestrictionCardiopulmonaryCell AgingCell BodyCell FunctionCell PhysiologyCell ProcessCell RespirationCell SenescenceCellsCellular AgingCellular FunctionCellular Immune FunctionCellular Metabolic ProcessCellular PhysiologyCellular ProcessCellular RespirationCellular SenescenceChronicClinicalCompetenceCounselingDataDevelopmentDevelopment PlansDiseaseDisorderDoseEducation for InterventionEducational InterventionExerciseExercise TestFundingFutureGene ExpressionGeroscienceGoalsHealthImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune MarkersImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunologic DiseasesImmunologic MarkersImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunomodulationImpairmentInflammationInflammatoryInflammatory ArthritisInstruction InterventionIntermediary MetabolismInterventionInvestigationKnowledgeLeadershipLife StyleLifestyleLinkMentorsMetabolic ProcessesMetabolismMitochondriaModelingMolecularMusculoskeletal Pain DisorderNational Institutes of HealthObesityOlder PopulationOrganPathway interactionsPatientsPeripheralPersonsPhlebotomyPhysical ExercisePhysical FitnessPhysiologyPilot ProjectsPlayPrescribed exerciseRandomizedRandomized, Controlled TrialsRegulatory T-LymphocyteReplicative SenescenceResearchRheumatic DiseasesRheumatismRheumatoid ArthritisRheumatologic DiseasesRheumatologic DisorderRheumatologyRoleSamplingScienceSkeletal MuscleStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStressSubcellular ProcessT-CellsT-LymphocyteTestingTrainingTraining InterventionTraining ProgramsTranslational Research EnterpriseTregUnited States National Institutes of HealthVenous blood samplingVoluntary MuscleWorkabove age 65adiposityaerobic metabolismaerobic respirationafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardage related pathwaysaged 65 and greateraged 65+aged ≥65aging associated mechanismaging mechanismaging pathwayaging related mechanismaging related pathwaysbiological mechanism of agebiological pathways of agebiological process of agebuild resiliencebuild resiliencycalorie restrictioncareercareer developmentcell metabolismcellular metabaolismchronic inflammatory diseaseclinical careclinical translationclinically translatablecombatcorpulencecytokinedecline in functiondecline in functional statusdevelop resiliencedevelop resiliencydevelopmentaldiet and exerciseelderly patientenhance resilienceenhance resiliencyexercise intensityexercise interventionexercise prescriptionexercise programexercise trainingexperienceextracellularfacilitate resiliencefitness programfunctional declinefunctional status declinegeroscientifichallmarks of aginghuman old age (65+)immune functionimmune healthimmune modulationimmune regulationimmune system healthimmune-based biomarkersimmunologic reactivity controlimmunological biomarkersimmunological markersimmunomodulatoryimmunoregulationimmunoregulatoryimprove resilienceimprove resiliencyimprovedincrease resilienceincrease resiliencyinstructional interventionlife style interventionlifestyle interventionmechanism regulating agingmechanisms involved in agingmitochondrialnovelolder adultolder adulthoodolder groupsolder individualsolder patientolder personover 65 yearsoxidative metabolismparent awardparent projectpathwaypathway involved in agingpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentphysical activity interventionpillars of agingpilot studypost interventionprematureprematurityprogramspromote resiliencepromote resiliencyrandomisationrandomizationrandomized control trialrandomly assignedrecruitregulatory T-cellsremote supervisionremotely supervisedreplicative agingresilienceresilience developmentresilientresponserheumatic arthritissafety assessmentsedentarysenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescentsenescent associated secretomesenescent associated secretory phenotypeskill acquisitionskill developmentskillssocial rolestatistical analysistherapeutic targetthymus derived lymphocytetranslation research enterprisetranslational research program≥65 years
Description preview
Abstract
Exercise training is linked to beneficial effects on maladaptive immune aging. In patients with rheumatoid
arthritis (RA), exercise training is a disease modulating therapy and may improve premature biological aging
inherent in RA, however, the mechanisms by which exercise benefits immune health is poorly understood.
Improved knowledge of…
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