grant
The effect of circadian rhythm disruptions on the angiogenic response to hypoperfusion in the AD brain
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 May 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20262-photon microscopyAD and related dementiaAD brainAD dementiaAD modelAD pathologyAD patientsAD related dementiaADRDAdventitial CellAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's brainAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease brainAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimer's patientAlzheimers DementiaAutoregulationBlood VesselsBrainBrain Nervous SystemCNS DiseasesCNS disorderCarotid Artery NarrowingCarotid Artery StenosisCarotid StenosisCell Culture TechniquesCentral Nervous System DiseasesCentral Nervous System DisordersCerebrovascular CirculationCerebrovascular InsufficiencyChronicCircadian DysregulationCircadian RhythmsCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommon carotid arteryCompensationComplexDataDependenceDisease ProgressionDisturbance in cognitionDoppler OCTDysfunctionEncephalonEndothelial CellsEndotheliumExhibitsFemaleFunctional disorderGenesHomeostasisImpaired cognitionImpairmentIn VitroKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeMeasuresMediatingMethodsMiceMice MammalsMurineMusNull MouseNyctohemeral RhythmOCT TomographyOptical Coherence TomographyOutcomePathologyPericapillary CellPericytesPeripheralPerivascular CellPhasePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPrimary Senile Degenerative DementiaRNA SeqRNA sequencingRNAseqRecoveryRouget CellsSleepTestingTwenty-Four Hour RhythmVascular remodelingage groupalzheimer modelangiogenesisawakeblood flow in brainbrain blood circulationbrain blood flowbrain endothelial cellbrain microvascular endothelial cellbrain vascular endothelial cellcell culturecell culturescell typecerebral blood flowcerebral circulationcerebral endothelial cellcerebral hypoperfusioncerebral microvascular endothelial cellcerebral vascular endothelial cellcerebrocirculationcerebrovascular blood flowcircadiancircadian abnormalitycircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakercircadian processcircadian rhythmicityco-morbidco-morbiditycognitive dysfunctioncognitive functioncognitive losscomorbiditydaily biorhythmdesigndesigningexperimentexperimental researchexperimental studyexperimentsglobal gene expressionglobal transcription profilehypoperfusionimprovedin vivomalemouse modelmultidisciplinarymurine modelnovelobject recognitionoptical Doppler tomographyoptical coherence Doppler tomographypathophysiologypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADprimary degenerative dementiaresponsesenile dementia of the Alzheimer typetranscriptometranscriptome sequencingtranscriptomic sequencingtwo photon excitation microscopytwo photon microscopyvascular♀♂
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PROJECT SUMMARY/ABSTRACT
Although the pathophysiology of Alzheimer’s Disease (AD) is complex and multifactorial, vascular comorbidities
and cerebrovascular insufficiency occur in almost two-thirds of AD patients. However, how cerebrovascular
insufficiency interacts with and contributes to AD remains poorly understood. Recently, the brain vasculome…
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